Pérez Tato Berta, Zamora Martínez Elena, Sánchez Albisua Begoña, Pérez González Yosmar C, Polimón Olabarrieta Isabel, Marinero Escobedo Silvia, Fernández López Paloma
Department of Dermatology, Hospital Universitario de Móstoles, Madrid, Spain.
Dermatol Online J. 2012 Mar 15;18(3):13.
Apocrine chromhidrosis is a rare, chronic, idiopathic disorder, characterized by the excretion of pigmented sweat. A 26-year-old woman presented with a 3-year history of dark blue secretions on bilateral malar cheeks. On examination, upon pressure on the cheeks, a dark blue fluid was expressed, which appeared to arise primarily from the follicle. The patient had not appreciated it, but on examination of her axillae, a very subtle blue coloring was observed. Histopathologic examination revealed apocrine glands in the deep reticular dermis. Bluish cytoplasmic granules were observed in the apocrine epithelium lining, which correspond to lipofuscin granules. The diagnosis of apocrine cromhidrosis was made. We began treatment with 20 percent aluminum chloride hexahydrate solution and capsaicin cream with poor tolerance. Finally, we treated with botulinum toxin type A with a successful response. We report a case of facial and axillary apocrine cromhidrosis with good response to botulinum toxin type A.
顶泌汗腺色汗症是一种罕见的慢性特发性疾病，其特征为排出有色汗液。一名26岁女性有双侧颊部深蓝色分泌物3年病史。检查时，按压脸颊可挤出深蓝色液体，该液体似乎主要来自毛囊。患者此前未注意到，但检查其腋窝时，观察到非常轻微的蓝色着色。组织病理学检查显示深网状真皮中有顶泌汗腺。在顶泌汗腺上皮衬里中观察到蓝色胞质颗粒，其对应于脂褐素颗粒。诊断为顶泌汗腺色汗症。我们开始用20%的六水合氯化铝溶液和辣椒素乳膏治疗，但耐受性差。最后，我们用A型肉毒毒素治疗，取得了成功的反应。我们报告一例面部和腋窝顶泌汗腺色汗症，对A型肉毒毒素反应良好。
