CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia.
Curr Opin Virol. 2012 Jun;2(3):242-7. doi: 10.1016/j.coviro.2012.03.006. Epub 2012 Apr 5.
Henipavirus, including Hendra and Nipah viruses, is a group of emerging bat-borne paramyxoviruses which were responsible for severe disease outbreaks in humans, horses and pigs. The mortality rate of human infection varies between 50 and 100%, making them one of the most deadly viruses known to infect humans. Its use of highly conserved cell surface molecules (ephrin) as entry receptors and its highly effective replication and fusion strategies are believed to be important characteristics responsible for its high pathogenicity. Henipavirus also encodes multiple accessory proteins which play a key role in evasion of host innate immune responses. Our recent study on the mechanism of IFN antagonism by henipaviruses indicated that a better understanding of the virus-host interaction provides great potential to develop new therapeutic strategies against these viruses.
亨尼帕病毒，包括亨德拉病毒和尼帕病毒，是一组新兴的蝙蝠传播副粘病毒，可导致人类、马和猪发生严重疾病暴发。人类感染的死亡率在 50%至 100%之间，使它们成为已知感染人类的最致命病毒之一。其使用高度保守的细胞表面分子（Ephrin）作为进入受体，以及其高效的复制和融合策略，被认为是导致其高致病性的重要特征。亨尼帕病毒还编码多种辅助蛋白，这些蛋白在逃避宿主固有免疫反应中发挥关键作用。我们最近对亨尼帕病毒抑制 IFN 的机制的研究表明，更好地了解病毒与宿主的相互作用为开发针对这些病毒的新治疗策略提供了巨大潜力。
