PEA 封端的 CdSe 和 ZnSe 量子点用于筛选人血清中的 C 反应蛋白。
CdSe and ZnSe quantum dots capped with PEA for screening C-reactive protein in human serum.
机构信息
Centro de Investigação em Química, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre 687, 4169-007 Porto, Portugal.
出版信息
Talanta. 2012 May 15;93:411-4. doi: 10.1016/j.talanta.2012.01.042. Epub 2012 Jan 25.
A fluorescence chemical sensor for C-reactive protein (CRP) was developed based on the selective interaction with CdSe and ZnSe quantum dots (QDs) coated with O-phosphorylethanolamine (PEA). Synthesis procedure and analytical parameters such as pH and ionic strength were studied. The decrease in the fluorescence emission intensity was explained due to the specific interaction of the QDs-PEA with CRP, and a correlation was observed between the quenching of the fluorescence and the concentration of CRP. The accuracy of the proposed method was 0.37% as RSD. The proposed method was applied to screen serum samples, and showed to be sensible at the C-reactive protein concentrations of risks levels.
基于与 CdSe 和 ZnSe 量子点（QDs）与 O-磷酰乙醇胺（PEA）涂层的选择性相互作用，开发了一种用于 C-反应蛋白（CRP）的荧光化学传感器。研究了合成程序和分析参数，如 pH 值和离子强度。荧光发射强度的降低可以解释为 QDs-PEA 与 CRP 的特异性相互作用，并且观察到荧光猝灭与 CRP 浓度之间存在相关性。所提出方法的准确性为 0.37%，相对标准偏差为 0.37%。该方法应用于筛选血清样品，并且在 C-反应蛋白浓度的风险水平上显示出灵敏性。
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