Stavreva Diana A, Varticovski Lyuba, Hager Gordon L
Laboratory of Receptor Biology and Gene Expression, Building 41, B507, 41 Library Dr., National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Biochim Biophys Acta. 2012 Jul;1819(7):657-66. doi: 10.1016/j.bbagrm.2012.03.004. Epub 2012 Mar 28.
Transcription is a tightly regulated cellular function which can be triggered by endogenous (intrinsic) or exogenous (extrinsic) signals. The development of novel techniques to examine the dynamic behavior of transcription factors and the analysis of transcriptional activity at the single cell level with increased temporal resolution has revealed unexpected elements of stochasticity and dynamics of this process. Emerging research reveals a complex picture, wherein a wide range of time scales and temporal transcription patterns overlap to generate transcriptional programs. The challenge now is to develop a perspective that can guide us to common underlying mechanisms, and consolidate these findings. Here we review the recent literature on temporal dynamics and stochastic gene regulation patterns governed by intrinsic or extrinsic signals, utilizing the glucocorticoid receptor (GR)-mediated transcriptional model to illustrate commonality of these emerging concepts. This article is part of a Special Issue entitled: Chromatin in time and space.
转录是一种受到严格调控的细胞功能，可由内源性（固有）或外源性（外在）信号触发。用于检测转录因子动态行为的新技术的发展以及在单细胞水平上以更高的时间分辨率对转录活性进行分析，揭示了这一过程中意想不到的随机性和动态性元素。新兴研究揭示了一幅复杂的图景，其中广泛的时间尺度和时间转录模式相互重叠以产生转录程序。现在的挑战是形成一种观点，能够引导我们找到共同的潜在机制，并整合这些发现。在这里，我们回顾了近期关于由内源性或外源性信号控制的时间动态和随机基因调控模式的文献，利用糖皮质激素受体（GR）介导的转录模型来说明这些新兴概念的共性。本文是名为：“时空染色质”的特刊的一部分。
