School of Psychological Science, Faculty of Science, Technology and Engineering, La Trobe University, Bundoora, Victoria 3086, Australia.
Pharmacol Biochem Behav. 2012 Dec;103(2):353-8. doi: 10.1016/j.pbb.2012.08.014. Epub 2012 Aug 24.
Piracetam is an AMPAkine drug that may have a range of different mechanisms at the cellular level, and which has been shown to facilitate memory, amongst its other effects. This series of experiments demonstrated that a 10mg/kg dose of piracetam facilitated memory consolidation in the day-old chick when injected from immediately until 120min after weak training (i.e. using a 20% v/v concentration of methyl anthranilate) with the passive avoidance learning task. Administration of piracetam immediately after training led to memory facilitation which lasted for up to 24h following training. This dose of the AMPAkine was not shown to facilitate memory reconsolidation. These findings support the contention that application of the AMPAkine piracetam facilitates memory using a weak training task, and extend the range of actions previously noted with NMDA-related agents to those which also facilitate the AMPA receptor.
吡拉西坦是一种 AMPAkine 药物，可能在细胞水平上具有一系列不同的机制，并且已被证明除其他作用外还能促进记忆。这一系列实验表明，当以 20%（v/v）浓度的甲基蒽酰胺进行弱训练（即使用 20%（v/v）浓度的甲基蒽酰胺）时，10mg/kg 剂量的吡拉西坦可促进日龄小鸡在注射后立即至 120 分钟内的记忆巩固被动回避学习任务。在训练后立即给予吡拉西坦可导致记忆增强，持续时间长达训练后 24 小时。该剂量的 AMPAkine 并未显示可促进记忆再巩固。这些发现支持这样一种观点，即应用 AMPAkine 吡拉西坦可使用弱训练任务促进记忆，并将先前与 NMDA 相关药物相关的作用范围扩展到那些也促进 AMPA 受体的药物。
