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子宫内膜癌近距离放疗治疗共识。

Consensus on treatment of endometrium carcinoma with brachytherapy.

机构信息

Fundación Instituto Valenciano de Oncología (IVO), Valencia, Spain. jguinot@fi vo.org

出版信息

Clin Transl Oncol. 2012 Apr;14(4):263-70. doi: 10.1007/s12094-012-0794-2.

DOI:10.1007/s12094-012-0794-2
PMID:22484633
Abstract

Radiotherapy (RT) is commonly used as adjuvant treatment following hysterectomy and double oophorectomy in endometrial carcinoma. Prophylactic vaginal brachytherapy (BT) is the most common treatment in BT units. The PORTEC and GOG 99 studies have attempted to clarify the indications of BT and postoperative external RT, changing treatment standards. However, prophylactic BT regimens are very varied and there is currently no consensus on how to treat patients in terms of dose per fraction and number of fractions. Moreover, unoperated cases of endometrium are uncommon and there is limited experience in their treatment with BT. The 9th Consensus Meeting of the SEOR and SEFM Brachytherapy Group, held in Malaga on 11 March 2011, was therefore dedicated to "Brachytherapy in Endometrial Carcinoma". This article presents the consensus on treatment of endometrial carcinoma in operated (prophylactic vaginal BT) and unoperated (endouterine BT) patients.

摘要

放疗(RT)常用于子宫内膜癌子宫切除和双侧卵巢切除术后的辅助治疗。预防性阴道近距离放疗(BT)是 BT 单位中最常见的治疗方法。PORTEC 和 GOG 99 研究试图阐明 BT 和术后外照射 RT 的适应证,改变了治疗标准。然而,预防性 BT 方案差异很大,目前对于如何根据分次剂量和分次次数来治疗患者尚无共识。此外,未手术的子宫内膜病例并不常见,用 BT 治疗的经验有限。因此,2011 年 3 月 11 日在马拉加举行的 SEOR 和 SEFM 近距离治疗小组第 9 次共识会议专门讨论了“子宫内膜癌的近距离治疗”。本文介绍了手术(预防性阴道 BT)和未手术(经阴道 BT)患者子宫内膜癌治疗的共识。

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本文引用的文献

1
Three or four fractions of 4-5 Gy per week in postoperative high-dose-rate brachytherapy for endometrial carcinoma.术后高剂量率近距离放疗治疗子宫内膜癌,每周进行 3 至 4 次,每次 4 至 5 Gy。
Int J Radiat Oncol Biol Phys. 2011 Oct 1;81(2):418-23. doi: 10.1016/j.ijrobp.2010.06.001. Epub 2010 Aug 26.
2
Consensus on 3D treatment planning in gynaecologic brachytherapy of the Radiation Oncology Spanish Society (SEOR) Brachytherapy Group.西班牙放射肿瘤学会(SEOR)近距离治疗组关于妇科近距离治疗的 3D 治疗计划的共识。
Clin Transl Oncol. 2010 Mar;12(3):181-7. doi: 10.1007/s12094-010-0488-6.
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Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial.
阴道限制用于减少子宫内膜癌术后近距离放疗后G2期晚期阴道并发症的初步结果:一项前瞻性分析
Clin Transl Oncol. 2022 May;24(5):875-881. doi: 10.1007/s12094-021-02737-z. Epub 2021 Dec 1.
4
Postoperative endometrial carcinoma treated with external beam irradiation plus vaginal-cuff brachytherapy. Is there a dose relationship with G2 vaginal complications?接受体外照射加阴道残端近距离放疗治疗的术后子宫内膜癌。与2级阴道并发症是否存在剂量关系?
Rep Pract Oncol Radiother. 2020 Mar-Apr;25(2):227-232. doi: 10.1016/j.rpor.2020.01.002. Epub 2020 Jan 14.
5
Late G2 vagina toxicity in post-operative endometrial carcinoma is associated with a 68 Gy dose equivalent to 2 Gy per fraction at 2 cm of vagina.子宫内膜癌术后阴道晚期G2毒性与阴道2 cm处相当于每次分割2 Gy的68 Gy剂量相关。
J Contemp Brachytherapy. 2018 Feb;10(1):40-46. doi: 10.5114/jcb.2018.74140. Epub 2018 Feb 28.
6
Vaginal-cuff control and toxicity results of a daily HDR brachytherapy schedule in endometrial cancer patients.子宫内膜癌患者每日高剂量率近距离放疗方案的阴道残端控制情况及毒性结果
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7
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Daily schedule for high-dose-rate brachytherapy in postoperative treatment of endometrial carcinoma.子宫内膜癌术后高剂量率近距离放疗的日常安排。
Clin Transl Oncol. 2013 Feb;15(2):111-6. doi: 10.1007/s12094-012-0893-0. Epub 2012 Jul 19.
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BJOG. 2007 Nov;114(11):1313-20. doi: 10.1111/j.1471-0528.2007.01332.x. Epub 2007 Sep 5.
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Intravaginal 1-week high-dose-rate brachytherapy alone for Stages I-II endometrial cancer.单纯阴道内1周高剂量率近距离放射疗法治疗Ⅰ-Ⅱ期子宫内膜癌。
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American Brachytherapy Society survey regarding practice patterns of postoperative irradiation for endometrial cancer: current status of vaginal brachytherapy.美国近距离放射治疗学会关于子宫内膜癌术后放疗实践模式的调查:阴道近距离放射治疗的现状
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Int J Radiat Oncol Biol Phys. 2005 Nov 1;63(3):834-8. doi: 10.1016/j.ijrobp.2005.03.007. Epub 2005 May 31.