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与美白牙膏相关的牙釉质病变的体外研究

In vitro study on tooth enamel lesions related to whitening dentifrice.

作者信息

de Araújo Danilo Barral, Silva Luciana Rodrigues, Campos Elisângela de Jesus, Correia de Araújo Roberto Paulo

机构信息

Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, Brazil.

出版信息

Indian J Dent Res. 2011 Nov-Dec;22(6):770-6. doi: 10.4103/0970-9290.94665.

Abstract

BACKGROUND

The tooth whitening substances for extrinsic use that are available in Brazil contain hydrogen peroxide or carbamide peroxide. Several studies have attributed the appearance of lesions in the enamel morphology, including hypersensitivity, to these substances. Such lesions justify fluoride therapy and application of infrared lasers, among other procedures. However, there is no consensus among researchers regarding the relevance of the severity of lesions detected on the tooth surface.

OBJECTIVES

The present study was carried out with an aim of evaluating in vitro the effects of the hydrogen peroxide, carbamide peroxide and sodium bicarbonate contained in dentifrice formulations, on human tooth enamel.

MATERIALS AND METHODS

After darkening process in laboratory, human premolars were brushed using dentifrice containing the two whitening substances (Rembrandt - carbamide peroxide and Mentadent - hydrogen peroxide) and the abrasive product (Colgate - sodium bicarbonate). The degree of specimen staining before and after this procedure was determined using spectrophotometry. Scanning electron microscopy (SEM) was used to obtain images, which were analyzed to show the nature of the lesions that appeared on the enamel surface.

RESULTS

The effectiveness of the whitening caused by hydrogen peroxide and carbamide peroxide and the abrasion caused by bicarbonate were confirmed, given that the treated test pieces returned to their original coloration. Based on SEM, evaluation of the enamel surfaces subjected to the test products showed that different types of morphologic lesions of varying severity appeared.

CONCLUSIONS

Whitening dentifrice containing hydrogen peroxide and carbamide peroxide produced lesions on the enamel surface such that the greatest sequelae were associated with exposure to hydrogen peroxide.

摘要

背景

巴西市面上可买到的用于外部的牙齿美白物质含有过氧化氢或过氧化脲。多项研究将牙釉质形态出现的病变,包括牙齿敏感,归因于这些物质。此类病变使得氟化物疗法以及红外激光应用等操作成为必要。然而,研究人员对于在牙齿表面检测到的病变严重程度的相关性尚未达成共识。

目的

本研究旨在体外评估牙膏配方中所含的过氧化氢、过氧化脲和碳酸氢钠对人牙釉质的影响。

材料与方法

在实验室进行染色处理后,使用含有两种美白物质(美白达 - 过氧化脲和曼特适 - 过氧化氢)以及研磨产品(高露洁 - 碳酸氢钠)的牙膏对人前磨牙进行刷牙。使用分光光度法测定此操作前后标本的染色程度。使用扫描电子显微镜(SEM)获取图像,并对其进行分析以显示牙釉质表面出现的病变性质。

结果

鉴于处理后的试件恢复到了原来的颜色,证实了过氧化氢和过氧化脲导致的美白效果以及碳酸氢钠造成的磨损。基于扫描电子显微镜,对接受测试产品处理的牙釉质表面的评估显示出现了不同类型、严重程度各异的形态学病变。

结论

含有过氧化氢和过氧化脲的美白牙膏会在牙釉质表面产生病变,其中最大的后遗症与接触过氧化氢有关。

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