Suzuki A, Tizard E J, Gooch V, Dillon M J, Haworth S G
Department of Paediatric Cardiology, Hospital for Sick Children, London.
Arch Dis Child. 1990 Oct;65(10):1142-6. doi: 10.1136/adc.65.10.1142.
Ninety-one patients with Kawasaki disease were examined by cross sectional echocardiography between 1980 and 1988. In the 75 patients evaluated during the acute phase of the illness (the first month), the first echocardiographic examination was carried out at a mean time of 16 days (range 5-30) and coronary arterial lesions were seen in 21 (28%). Two patients with medium sized aneurysms had myocardial infarctions, and one died. Coronary arterial lesions persisted in 17 (23%) patients, most often in younger children. The remaining 16 patients were examined from one month to four years after their acute illnesses, and this group did not have coronary arterial abnormalities. Seven patients with coronary artery lesions have reached school age and require regular echocardiographic examination and exercise electrocardiography. Selective coronary arteriography may be indicated in some patients to identify coronary artery stenosis, which the Japanese experience has shown may progress for several years after the acute illness.
1980年至1988年间,对91例川崎病患者进行了横断面超声心动图检查。在疾病急性期(第一个月)评估的75例患者中,首次超声心动图检查的平均时间为16天(范围5 - 30天),21例(28%)可见冠状动脉病变。两名患有中等大小动脉瘤的患者发生心肌梗死,一名死亡。17例(23%)患者的冠状动脉病变持续存在,最常见于年幼儿童。其余16例患者在急性病后1个月至4年接受检查,该组未发现冠状动脉异常。7例有冠状动脉病变的患者已达到学龄,需要定期进行超声心动图检查和运动心电图检查。在一些患者中可能需要进行选择性冠状动脉造影以确定冠状动脉狭窄,日本的经验表明,急性病后冠状动脉狭窄可能会持续数年。