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共生菌群，作为自身免疫性胰腺炎的触发因素，是不受欢迎的“伙伴”吗？

Commensal Flora, is it an Unwelcomed Companion as a Triggering Factor of Autoimmune Pancreatitis?

作者信息

Haruta Ikuko, Shimizu Kyoko, Yanagisawa Naoko, Shiratori Keiko, Yagi Junji

机构信息

Department of Microbiology and Immunology, Tokyo Women's Medical University Tokyo, Japan.

出版信息

Front Physiol. 2012 Apr 2;3:77. doi: 10.3389/fphys.2012.00077. eCollection 2012.

DOI:10.3389/fphys.2012.00077
PMID:22485093
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3317269/
Abstract

The etiopathogenesis of many autoimmune disorders has not been identified. The aim of this paper is to focus on the involvement of bacterial exposure, as an environmental factor, in the pathogenesis of autoimmune pancreatitis (AIP), which is broadly categorized as autoimmune disorders involving pancreatic lesions. Avirulent and/or commensal bacteria, which may have an important role(s) as initiating/progressing factors in the pathogenesis of autoimmune disorder AIP, will be emphasized.

摘要

许多自身免疫性疾病的发病机制尚未明确。本文旨在聚焦细菌暴露这一环境因素在自身免疫性胰腺炎（AIP）发病机制中的作用，AIP被广泛归类为涉及胰腺病变的自身免疫性疾病。无毒和/或共生细菌作为自身免疫性疾病AIP发病机制中的起始/进展因素可能具有重要作用，这将是本文重点强调的内容。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c214/3317269/c7819ea262dc/fphys-03-00077-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c214/3317269/c7819ea262dc/fphys-03-00077-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c214/3317269/c7819ea262dc/fphys-03-00077-g001.jpg

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本文引用的文献

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Pro-resolution immunological networks: binding immunoglobulin protein and other resolution-associated molecular patterns.促炎消退免疫网络：结合免疫球蛋白蛋白和其他消退相关的分子模式。
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Are dysregulated inflammatory responses to commensal bacteria involved in the pathogenesis of hepatobiliary-pancreatic autoimmune disease? An analysis using mice models of primary biliary cirrhosis and autoimmune pancreatitis.
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Recent advances in pancreatology.胰腺病学的最新进展。
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ISRN Gastroenterol. 2011;2011:513514. doi: 10.5402/2011/513514. Epub 2011 Jun 15.
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Involvement of activation of toll-like receptors and nucleotide-binding oligomerization domain-like receptors in enhanced IgG4 responses in autoimmune pancreatitis.Toll样受体和核苷酸结合寡聚化结构域样受体的激活在自身免疫性胰腺炎IgG4反应增强中的作用
Arthritis Rheum. 2012 Mar;64(3):914-24. doi: 10.1002/art.33386.
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Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related disease.自身免疫性胰腺炎和 IgG4 相关疾病概念和诊断的最新进展。
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Commensal flora and the regulation of inflammatory and autoimmune responses.共生菌群与炎症和自身免疫反应的调节。
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Lipooligosaccharide of Campylobacter jejuni: similarity with multiple types of mammalian glycans beyond gangliosides.空肠弯曲菌的脂寡糖：与神经节苷脂以外的多种哺乳动物聚糖的相似性。
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