Yanagisawa Naoko, Haruta Ikuko, Kikuchi Ken, Shibata Noriyuki, Yagi Junji
Departments of Infection Control Science and Bacteriology, School of Medicine, Juntendo University, Tokyo 113-8421, Japan Departments of Microbiology and Immunology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, Japan.
ISRN Gastroenterol. 2011;2011:513514. doi: 10.5402/2011/513514. Epub 2011 Jun 15.
The etiopathogenesis of many autoimmune disorders has not been identified. The aim of this paper is to focus on the involvement of bacterial exposure in the pathogenesis of primary biliary cirrhosis (PBC) and autoimmune pancreatitis (AIP), both of which are broadly categorized as autoimmune disorders involving hepatobiliary-pancreatic lesions. Avirulent and/or commensal bacteria, which may have important role(s) as initiating factors in the pathogenesis of autoimmune disorders such as PBC and AIP, will be emphasized.
许多自身免疫性疾病的发病机制尚未明确。本文旨在聚焦细菌暴露在原发性胆汁性肝硬化（PBC）和自身免疫性胰腺炎（AIP）发病机制中的作用，这两种疾病都被广泛归类为涉及肝胆胰病变的自身免疫性疾病。无毒力和/或共生细菌可能作为PBC和AIP等自身免疫性疾病发病机制中的起始因素发挥重要作用，这将是本文重点强调的内容。
