Mitchell R E, Mitchell R M, Shugg D, Wyld C
Aust N Z J Surg. 1979 Jun;49(3):305-12.
Histopathology data from 298 patients with breast cancer have been stored in a computer, and features influencing survival have been analysed by the life table method and presented in survival curves. Prognostic features assessed were the size, type, and grade of neoplasm, the amount of stromal elastosis and lymphocytic infiltrate, and the presence and number of axillary metastases. The most reliable indications of short survival are the presence of axillary metastases and a high tumour grade. These two features are correlated, as high-grade tumours are much more likely to have metastases at presentation. No statistical difference is found in the survival of patients with metastases in one or two axillary nodes compared with those with larger numbers involved. There are differences in survival in different types of carcinoma; the well-differentiated infiltrating duct carcinoma with tubular pattern has the best prognosis, followed by the medullary carcinoma. The size of the tumour has some prognostic significance, but this is outweighed by its grade.
来自298例乳腺癌患者的组织病理学数据已存储在计算机中，通过生命表法分析了影响生存的特征，并绘制了生存曲线。评估的预后特征包括肿瘤的大小、类型和分级、间质弹性组织变性和淋巴细胞浸润的程度，以及腋窝转移的有无和数量。生存时间短的最可靠指标是腋窝转移的存在和高肿瘤分级。这两个特征是相关的，因为高分级肿瘤在就诊时更有可能发生转移。与腋窝淋巴结转移数目较多的患者相比，腋窝一两个淋巴结转移的患者生存率无统计学差异。不同类型的癌生存率存在差异；具有管状结构的高分化浸润性导管癌预后最好，其次是髓样癌。肿瘤大小具有一定的预后意义，但其分级更为重要。
