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[烧伤后甘油保存的同种异体中厚皮片应用的适应证及结果]

[Indication for and results of the application of glycerol-preserved homologous split-thickness skin following burns].

作者信息

Bruck J C, Büttemeyer R, Grabosch A, Weyer A

机构信息

Abteilung Plastische Chirurgie, Krankenhaus Am Urban, Berlin/West.

出版信息

Beitr Orthop Traumatol. 1990 Sep;37(9):504-6.

PMID:2248607
Abstract

Since 1983 the treatment of second-degree burns with glycerol-conserved allogenic split-thickness skin grafts is published. In case of actual problems with AIDS the gathering of split-thickness skin was modified and a new method for gaining split-thickness skin of organ-donors created to prevent the virus transfer. Because of these high security in contagiousness the skin graft transplantation with allogenic glycerol-conserved donor-skin in case of second-degree-burns was standardized in the Berlin Burn Center. To prevent the formation of granulation tissue after second-degree burns a tangential debridement of necrotic corium will be done in 1/10 mm thick slices on the third posttraumatic day and the defects covered with 1:1.5 mesh grafts extended. The results of 267 patients in 1988 and 1989, who were treated in accordance to this regimen, will be demonstrated. In 11% of cases the alloplastic skin graft in adults was not rejected 6 month after transplantation and in 2% of cases the depth of burn was not estimated properly and hypertrophic scars had to be excised and covered with autogenous split-thickness skin. General second-degree-burn healed after debridement and covering with allogeneic split-thickness skin without formation of hypertrophic scars.

摘要

自1983年起,甘油保存的同种异体中厚皮片用于治疗二度烧伤的相关内容已发表。在艾滋病出现实际问题的情况下,中厚皮片采集方法进行了改进,并开创了一种获取器官捐献者中厚皮片的新方法以防止病毒传播。鉴于这种在传染性方面的高度安全性,柏林烧伤中心对二度烧伤时使用同种异体甘油保存的供皮进行皮肤移植手术进行了标准化。为防止二度烧伤后肉芽组织形成,在创伤后第三天对坏死真皮进行1/10毫米厚的削痂,并覆盖1:1.5网孔的皮片。将展示1988年和1989年按照该方案治疗的267例患者的结果。在11%的病例中,成人的异体皮移植在移植6个月后未被排斥,在2%的病例中,烧伤深度估计不当,不得不切除增生性瘢痕并用自体中厚皮覆盖。一般二度烧伤在清创并用异体中厚皮覆盖后愈合,未形成增生性瘢痕。

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