Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, DK-2900 Hellerup, Denmark.
Contact Dermatitis. 2012 May;66(5):279-85. doi: 10.1111/j.1600-0536.2011.02053.x.
Chromium-tanned leather footwear, which releases >3 ppm hexavalent Cr(VI), may pose a risk of sensitizing and eliciting allergic dermatitis.
To determine the content and potential release of chromium in leather footwear and to discuss the prevention of chromium contact allergy and dermatitis.
Sixty pairs of leather shoes, sandals and boots (20 children's, 20 men's, and 20 women's) were purchased in Copenhagen and examined with X-ray fluorescence spectroscopy. Chromium was extracted according to the International Standard, ISO 17075. The detection level for Cr(VI) was 3 ppm.
Chromium was identified in 95% of leather footwear products, the median content being 1.7% (range 0-3.3%). No association with store category or footwear category was found. A tendency for there to be a higher chromium content in footwear with high prices was shown (p(trend) = 0.001). Cr(VI) was extracted from 44% of 18 footwear products, and, in three items, more than 10 ppm was extracted. One shoe had 62 ppm Cr(VI) extracted. Sandals seemed to be over-represented among footwear with detectable Cr(VI). Cr(III) extraction reached a median value of 152 ppm.
Most leather footwear contained chromium. Cr(VI) was extracted from a high proportion of leather footwear; this poses a risk of sensitization.
释放超过 3ppm 六价铬（Cr(VI)）的铬鞣革制鞋可能具有致敏性，并引发变应性接触性皮炎。
确定制鞋皮革中铬的含量和潜在释放量，并讨论预防铬接触过敏和皮炎的措施。
在哥本哈根购买了 60 双皮鞋、凉鞋和靴子（20 双儿童鞋、20 双男鞋和 20 双女鞋），并用 X 射线荧光光谱法进行检查。根据国际标准 ISO 17075 提取铬。Cr(VI) 的检测水平为 3ppm。
95%的鞋类产品中均检出铬，中位数含量为 1.7%（范围 0-3.3%）。未发现与商店类别或鞋类类别的关联。高价格的鞋类产品中铬含量较高的趋势（p(trend) = 0.001）。18 件鞋类产品中有 44%提取出了 Cr(VI)，其中三件产品的提取量超过 10ppm。有一只鞋提取出的 Cr(VI)含量达到 62ppm。凉鞋似乎在可检测 Cr(VI)的鞋类产品中占比较高。Cr(III)的提取中位数达到 152ppm。
大多数皮革制鞋都含有铬。大量皮革鞋类产品中提取出了 Cr(VI)，这可能引发致敏风险。
