合成肝素四糖作为人肝素酶的底物。
Synthesis of heparan sulfate tetrasaccharide as a substrate for human heparanase.
机构信息
Department of Regional Environment, Tottori University, Tottori 680-8551, Japan.
出版信息
Carbohydr Res. 2012 May 15;353:13-21. doi: 10.1016/j.carres.2012.03.014. Epub 2012 Mar 20.
PMID:22486828
Abstract
Regiospecifically sulfated heparan sulfate tetrasaccharide, GlcAβ-GlcN(NS6S)α-GlcAβ-GlcN(NS6S)α was first synthesized as an octyl glycoside. Total synthesis was achieved effectively by coupling the corresponding disaccharide units in short steps.
摘要
首次将具有区域选择性的硫酸化乙酰肝素四糖 GlcAβ-GlcN(NS6S)α-GlcAβ-GlcN(NS6S)α 合成为辛基糖苷。通过短步骤有效地偶联相应的二糖单元，实现了全合成。
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