基于反应的硫化氢荧光探针。
Reaction based fluorescent probes for hydrogen sulfide.
机构信息
Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.
出版信息
Org Lett. 2012 Apr 20;14(8):2184-7. doi: 10.1021/ol3008183. Epub 2012 Apr 9.
Abstract
A reaction based fluorescence turn-on strategy for hydrogen sulfide (H(2)S) was developed. This strategy was based on a H(2)S-specific Michael addition-cyclization sequence. Other biological thiols such as cysteine and glutathione did not pursue the reaction and therefore did not turn on the fluorescence/consume the substrates. The probes showed good selectivity and sensitivity for hydrogen sulfide.
摘要
开发了一种基于反应的荧光开启策略用于检测硫化氢（H2S）。该策略基于 H2S 特异性的迈克尔加成-环化序列。其他生物硫醇，如半胱氨酸和谷胱甘肽，不会进行该反应，因此不会开启荧光/消耗底物。探针对硫化氢具有良好的选择性和灵敏度。
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