Pu Youzhen, Lin Wenlong, Ren Suyi, Gao Yuxu, Wang Guiming
Department of Vascular Surgery, the First Affiliated Hospital of Shanxi Medical University, Shanxi, China.
J Cardiovasc Pharmacol. 2025 May 30. doi: 10.1097/FJC.0000000000001714.
Hydrogen sulfide (H 2 S), an important gaseous signaling molecule, plays a critical role in maintaining vascular homeostasis. H 2 S participates in numerous biological functions, including redox regulation, interactions with other signaling molecules, and post-translational modifications of proteins through sulfhydration. Additionally, H 2 S influences key pathological processes such as inflammation, oxidative stress, and cell apoptosis. Dysregulation of endogenous H 2 S metabolism has been closely linked to the development of various vascular diseases, including aortic aneurysms, aortic dissection, atherosclerosis, and thrombotic conditions. Various endogenous and exogenous H 2 S donors have been developed, and these donors have demonstrated promising effects in preclinical models of vascular diseases such as atherosclerosis, pulmonary hypertension, and thrombosis by modulating oxidative stress, inflammatory pathways, and vascular remodeling. This review consolidates the current knowledge on the effects of H 2 S on vascular function and offers a comprehensive summary of recent advancements in the development and application of H 2 S donors in vascular disease research.
硫化氢（H₂S）是一种重要的气体信号分子，在维持血管稳态中发挥关键作用。H₂S参与多种生物学功能，包括氧化还原调节、与其他信号分子的相互作用以及通过硫氢化作用对蛋白质进行翻译后修饰。此外，H₂S影响关键的病理过程，如炎症、氧化应激和细胞凋亡。内源性H₂S代谢失调与各种血管疾病的发生密切相关，包括主动脉瘤、主动脉夹层、动脉粥样硬化和血栓形成。已经开发了各种内源性和外源性H₂S供体，这些供体通过调节氧化应激、炎症途径和血管重塑，在动脉粥样硬化、肺动脉高压和血栓形成等血管疾病的临床前模型中显示出有前景的效果。本综述巩固了关于H₂S对血管功能影响的现有知识，并全面总结了H₂S供体在血管疾病研究中的开发和应用的最新进展。
