Key Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education, Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, 411201, Hunan, China.
Lab of Biochemical Sensing Technology, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.
Anal Bioanal Chem. 2022 Apr;414(9):2809-2839. doi: 10.1007/s00216-021-03777-8. Epub 2021 Nov 26.
Hydrogen sulfide (HS) is a biologically signaling molecule that mediates a wide range of physiological functions, which is frequently misregulated in numerous pathological processes. As such, measurement of HS holds great attention due to its unique physiological and pathophysiological roles. Currently, a variety of methods based on the HS-involved reactions have been reported for detection of endogenous HS, bearing the advantages of good specificity and high sensitivity. This review describes in detail the types of reactions, their mechanisms, and their applications in biological research, thus hopefully providing some guidelines to the researchers in this field for further investigation.
硫化氢（HS）是一种生物信号分子，介导广泛的生理功能，在许多病理过程中经常失调。因此，由于其独特的生理和病理生理作用，HS 的测量受到了极大的关注。目前，已经报道了基于 HS 参与的反应的各种方法来检测内源性 HS，这些方法具有良好的特异性和高灵敏度的优点。本综述详细描述了这些反应的类型、机制及其在生物研究中的应用，希望为该领域的研究人员提供进一步研究的指导。
