Digestive Health Institute, Pediatric Liver Center, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO 80045, USA.
J Pediatr Gastroenterol Nutr. 2012 Jun;54(6):838-55. doi: 10.1097/MPG.0b013e318258328d.
Hepatitis C virus (HCV) is an RNA virus that affects >180 million individuals worldwide with a high propensity for chronic infection. Children with HCV infection differ from adults in several ways including some modes of transmission, rates of clearance, progression of fibrosis, and the duration of potential chronic infection when acquired at birth. Since the discovery of HCV in 1989, there have been significant advances in the understanding of the virology and natural history of chronic HCV infection in children. In addition, there are now several treatment options for children with chronic hepatitis C infection and many new therapies on the horizon. As a consequence, the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition brought together experts in pediatric hepatology to review the available data in children and provide clinicians with approaches to the diagnosis, management, and prevention of HCV infection in children and adolescents. The guideline details the epidemiology and natural history of HCV infection in children, the diagnostic workup, monitoring and treatment of disease, and provides an update on future treatment options and areas of research.
丙型肝炎病毒 (HCV) 是一种 RNA 病毒，影响全球超过 1.8 亿人，具有高度慢性感染倾向。丙型肝炎病毒感染的儿童在传播途径、清除率、纤维化进展和出生时获得的潜在慢性感染持续时间等方面与成人不同。自 1989 年发现 HCV 以来，人们对儿童慢性 HCV 感染的病毒学和自然史有了更深入的了解。此外，目前针对儿童慢性丙型肝炎感染有多种治疗选择，并且有许多新的治疗方法即将问世。因此，北美儿科学会胃肠病学、肝脏病学和营养学召集了儿科肝脏病学专家，回顾了儿童中的现有数据，并为临床医生提供了诊断、管理和预防儿童和青少年丙型肝炎感染的方法。该指南详细介绍了 HCV 感染在儿童中的流行病学和自然史、诊断方法、疾病监测和治疗，并提供了有关未来治疗选择和研究领域的最新信息。
