Department of Medicine, University of Padova, Italy.
Biofactors. 2012 May-Jun;38(3):194-202. doi: 10.1002/biof.1016. Epub 2012 Apr 10.
Diabetes mellitus is associated with an increased risk of cardiovascular disease due to its negative impact on the vascular endothelium. The damaged endothelium is repaired by resident cells also through the contribution of a population of circulating cells derived from bone marrow. These cells, termed endothelial progenitor cells (EPCs) are involved in maintaining endothelial homeostasis and contributes to the formation of new blood vessels with a process called postnatal vasculogenesis. The mechanisms whereby these cells allow for protection of the cardiovascular system are still unclear; nevertheless, consistent evidences have shown that impairment and reduction of EPCs are hallmark features of type 1 and type 2 diabetes. Therefore, EPC alterations might have a pathogenic role in diabetic complications, thus becoming a potential therapeutic target. In this review, EPC alterations will be examined in the context of macrovascular and microvascular complications of diabetes, highlighting their roles and functions in the progression of the disease.
糖尿病与心血管疾病风险增加有关，因为它对血管内皮有负面影响。受损的内皮通过来自骨髓的循环细胞群的贡献也由常驻细胞修复。这些细胞，称为内皮祖细胞 (EPC)，参与维持内皮稳态，并有助于通过称为出生后血管生成的过程形成新的血管。这些细胞允许保护心血管系统的机制尚不清楚；然而，一致的证据表明，EPC 的损伤和减少是 1 型和 2 型糖尿病的特征性特征。因此，EPC 的改变可能在糖尿病并发症中具有致病作用，从而成为潜在的治疗靶点。在这篇综述中，将检查 EPC 改变在糖尿病大血管和微血管并发症中的情况，强调它们在疾病进展中的作用和功能。
