Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Japan.
Angew Chem Int Ed Engl. 2012 May 14;51(20):4972-5. doi: 10.1002/anie.201201383. Epub 2012 Apr 5.
Ring functionalization: the total synthesis of a natural derivative of (-)-13-oxyingenol, a potent anti-HIV diterpenoid, is reported. The key steps in this synthesis include a ring-closing olefin metathesis and a Mislow-Evans-type [2,3]-sigmatropic rearrangement. This synthesis provides access to (-)-13-oxyingenol and its natural derivative in 21 steps from a synthetic intermediate previously prepared by Kigoshi and co-workers.
报道了一种天然 (-)-13-氧异沉香醇衍生物的全合成， (-)-13-氧异沉香醇是一种有效的抗 HIV 二萜。该合成中的关键步骤包括环 closing 烯丙基复分解反应和 Mislow-Evans 型 [2,3]-σ重排。该合成提供了从 Kigoshi 及其同事先前制备的合成中间体出发，以 21 步得到 (-)-13-氧异沉香醇及其天然衍生物的途径。
