Department of Ophthalmology, Gaziosmanpasa University School of Medicine, Tokat, Turkey.
Acta Ophthalmol. 2012 Aug;90(5):e349-54. doi: 10.1111/j.1755-3768.2012.02432.x. Epub 2012 Apr 10.
To evaluate the effects of chronic obstructive pulmonary disease (COPD) on retina and optic nerve.
Thirty-eight patients with COPD and 29 healthy controls, totally 67 subjects, were included in the study. Visual evoked potentials (VEP) and visual field assessment (both standard achromatic perimetry (SAP) and short-wavelength automated perimetry (SWAP)) were performed on each subject after ophthalmological, neurological and pulmonary examinations.
Mean deviation (MD), pattern standard deviation (PSD) and corrected pattern standard deviation (CPSD) were significantly different between patient and control groups as for both SAP and SWAP measurements (p = 0.001, 0.019, 0.009 and p = 0.004,0.019, 0.031, respectively). Short-term fluctuation (SF) was not statistically different between the study and the control groups (p = 0.874 and 0.694, respectively). VEP P100 latencies were significantly different between patients with COPD and the controls (p = 0.019).
Chronic obstructive pulmonary disease is a systemic disease, and hypoxia in COPD seems to affect the retina and the optic nerve.
评估慢性阻塞性肺疾病（COPD）对视网膜和视神经的影响。
共纳入 38 例 COPD 患者和 29 例健康对照者（共 67 例受试者）。对所有受试者进行眼科、神经科和肺功能检查后，行视觉诱发电位（VEP）和视野检查（标准全色视野检查和短波长自动化视野检查）。
与对照组相比，COPD 患者的 SAP 和 SWAP 测量的平均偏差（MD）、模式标准差（PSD）和校正模式标准差（CPSD）差异均有统计学意义（p=0.001、0.019、0.009 和 p=0.004、0.019、0.031，分别）。两组间短期波动（SF）差异无统计学意义（p=0.874 和 0.694，分别）。COPD 患者的 VEP P100 潜伏期与对照组相比差异有统计学意义（p=0.019）。
慢性阻塞性肺疾病是一种全身性疾病，COPD 中的缺氧似乎会影响视网膜和视神经。
