Mikaeili Haleh, Yazdchi Mohammad, Solahaye Kahnamouii Shiva, Sadeghi-Hokmabadi Elyar, Mirnour Reshad
Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Science, Tabriz, Iran.
Neuroscience Research Center, Tabriz University of Medical Science, Tabriz, Iran.
Clin Ophthalmol. 2015 Feb 9;9:271-5. doi: 10.2147/OPTH.S75804. eCollection 2015.
Chronic obstructive pulmonary disease (COPD) is a major public health problem worldwide. The aim of this study was to evaluate the rate of optic neuropathy in COPD patients.
Forty patients diagnosed with COPD and 60 healthy subjects as control group enrolled. After examination by a pulmonary subspecialist, patients were ranked by Global initiative for chronic Obstructive Lung Disease (GOLD) criteria, and patients with zero grades on GOLD criteria were excluded. Visual evoked potential by checkerboard (raster background) method with a frequency of 2 Hz were done for all participants. P-values less than 0.05 were considered as significant.
Fifty-five percent of COPD patients had visual evoked potential abnormalities. Mean P100 latency in both eyes was significantly longer in COPD patients. Average P100/N140 amplitude in both eyes were insignificantly higher in COPD.
Higher P100 latency in COPD patients shows demyelinating type of optic nerve involvement; however, further investigation in this area is needed.
慢性阻塞性肺疾病（COPD）是全球主要的公共卫生问题。本研究的目的是评估COPD患者视神经病变的发生率。
纳入40例诊断为COPD的患者和60例健康受试者作为对照组。经肺科专科医生检查后，根据慢性阻塞性肺疾病全球倡议（GOLD）标准对患者进行分级，排除GOLD标准为零级的患者。对所有参与者采用棋盘格（光栅背景）法，以2Hz的频率进行视觉诱发电位检查。P值小于0.05被认为具有统计学意义。
55%的COPD患者存在视觉诱发电位异常。COPD患者双眼的平均P100潜伏期明显延长。COPD患者双眼的平均P100/N140波幅略高，但无统计学意义。
COPD患者较高的P100潜伏期表明视神经受累为脱髓鞘类型；然而，该领域需要进一步研究。
