Woo David, Leong James, Waring Dale, Sharma Alok, Martin Peter
Sydney Eye Hospital, Ophthalmology, 8 Macquarie Street, Sydney 2000, Australia.
Orbit. 2012 Apr;31(2):129-31. doi: 10.3109/01676830.2011.638100.
To report an uncommon case of orbital gastrointestinal stromal tumor (GIST) metastasis.
Observational case report.
A 65-year-old woman with metastatic GIST involving the left orbit with a history of two separate GIST nodules involving the stomach 6 years earlier. Computed tomography (CT) scan demonstrated a well-circumscribed enhancing lesion confined to the anterior orbit. Histopathology analysis of the tumor showed predominantly spindle cells with focal epithelioid forms. It also stained positive for c-KIT (CD117) on immunochemistry, confirming the diagnosis. Additional medical treatment was not required, and the patient was followed up regularly for disease recurrence.
GISTs typically occur as sporadic solitary tumors. In malignant cases, it usually metastasizes to the liver or other intraabdominal sites. Orbital involvement is extremely rare. This is the first case of metastatic GIST involving the anterior orbit with histopathological and immunochemical confirmation.
报告一例罕见的眼眶胃肠道间质瘤（GIST）转移病例。
观察性病例报告。
一名65岁女性，患有转移至左眼眶的GIST，6年前有两个分别位于胃部的GIST结节病史。计算机断层扫描（CT）显示一个边界清晰的强化病灶，局限于眼眶前部。肿瘤的组织病理学分析显示主要为梭形细胞，有局灶性上皮样形态。免疫化学检测其c-KIT（CD117）染色呈阳性，确诊为此病。无需额外的药物治疗，对患者进行定期随访以观察疾病复发情况。
GIST通常表现为散发性孤立肿瘤。在恶性病例中，它通常转移至肝脏或其他腹腔内部位。眼眶受累极为罕见。这是首例经组织病理学和免疫化学证实的累及眼眶前部的转移性GIST病例。
