Yu Yan, Ji Xiaoqian, Li Wei, Wu Changfan
Department of Ophthalmology, Yijishan Hospital of Wannan Medical College, Wuhu, 241000, China.
Am J Ophthalmol Case Rep. 2019 Aug 3;16:100528. doi: 10.1016/j.ajoc.2019.100528. eCollection 2019 Dec.
Gastrointestinal stromal tumor (GIST) is the most common primary mesenchymal tumor. The most common metastasis sites are the liver and the surface of the peritoneum. In this study, we present a case of orbital GIST metastasis.
A 43-year-old woman who had a history of small intestinal stromal tumor 4 years ago suffered GIST metastasis to the left orbit. MRI confirmed the presence of a lacrimal gland lesion with isointense on T1 and hyperintense on T2 weighted images. Histopathology analysis of the tumor showed predominantly spindle or oval cells with nuclear pleomorphism and increased mitoses. The tumor also stained positive for c-KIT (CD117) upon immunochemistry, confirming the diagnosis.
GISTs typically occur as sporadic solitary tumors, and their common metastasis sites are the liver and the surface of the peritoneum. Orbital involvement is extremely rare. The orbital GIST metastatic tumor has special imaging properties, as evidenced by histopathology, immunochemistry, and magnetic resonance imaging (MRI).
胃肠道间质瘤（GIST）是最常见的原发性间充质肿瘤。最常见的转移部位是肝脏和腹膜表面。在本研究中，我们报告一例眼眶GIST转移病例。
一名43岁女性，4年前有小肠间质瘤病史，现发生GIST转移至左眼眶。MRI证实泪腺有病变，在T1加权像上呈等信号，在T2加权像上呈高信号。肿瘤组织病理学分析显示主要为梭形或椭圆形细胞，有核异型性且有丝分裂增加。免疫化学检测肿瘤c-KIT（CD117）染色呈阳性，确诊。
GIST通常表现为散发性孤立肿瘤，其常见转移部位是肝脏和腹膜表面。眼眶受累极为罕见。眼眶GIST转移瘤具有特殊的影像学特征，组织病理学、免疫化学及磁共振成像（MRI）均证实了这一点。
