Roelofs Kelsey A, Medlicott Shaun, Henning Jan-Willem, Weis Ezekiel
Department of Ophthalmology and Visual Sciences, University of Alberta, Canada.
Department of Pathology.
Ophthalmic Plast Reconstr Surg. 2018 Jul/Aug;34(4):e131-e133. doi: 10.1097/IOP.0000000000001144.
A 66-year-old woman was referred to the authors' service with a 1-week history of blurry vision in her left eye and retro-orbital ache. She had previously undergone a radical distal gastrectomy and omentectomy for gastrointestinal stromal tumor, epithelioid type, 7 years prior. Exophthalmometry confirmed 2 mm of left-sided proptosis. Computed tomography imaging revealed a solid-appearing mass straddling both the intra- and extraconal spaces and involving the superior rectus muscle. An excisional biopsy was performed. Histopathological examination revealed a relatively uniform epithelioid appearance with a high mitotic rate, and immunohistochemical analysis revealed positivity for both KIT (CD117) and CD34. To the best of the authors' knowledge, this is only the second histopathologically confirmed case of gastrointestinal stromal tumor metastasis to the orbit reported in the literature.
一名66岁女性因左眼视力模糊和眶后疼痛1周前来作者所在科室就诊。她7年前曾因上皮样型胃肠道间质瘤接受过根治性远端胃切除术和网膜切除术。眼球突出度测量显示左侧眼球突出2毫米。计算机断层扫描成像显示一个实性肿块横跨肌锥内和肌锥外间隙，并累及上直肌。进行了切除活检。组织病理学检查显示外观相对一致的上皮样表现，有较高的有丝分裂率，免疫组化分析显示KIT（CD117）和CD34均呈阳性。据作者所知，这是文献中报道的第二例经组织病理学证实的胃肠道间质瘤眼眶转移病例。
