[2002年至2010年上海市杨浦区居民原发性肝癌的发病与生存状况]

[The occurrence and survival condition of primary liver cancer among residents in Yangpu district of Shanghai between year 2002 and 2010].

作者信息

Han Xue, Huang Chen-Xi, Zhang Hong-Wei, Qiao Peng, Xie Meng, Zhang Rong, Cao Guang-Wen

机构信息

Center of Disease Control and Prevention of Yangpu District, Shanghai 200090, China.

出版信息

Zhonghua Yu Fang Yi Xue Za Zhi. 2012 Feb;46(2):119-24.

PMID:22490192

Abstract

OBJECTIVE

To analyze the incidence and survival rates of primary liver cancer (PLC) among residents in Yangpu district of Shanghai.

METHODS

A total of 9 730 736 permanent residents (male 4 996 390 and female 4 734 346) of Yangpu district in Shanghai were recruited in the study between year 2002 and 2010; among whom 2726 PLC cases were diagnosed and 2427 death cases were certified. The incidence and mortality of PLC were calculated under the analysis of the new PLC cases and death cases between year 2002 and 2010. The rates were standardized by the demographic composition developed in the Fifth Nationwide Census in year 2000, in order to analyze the survival condition of PLC patients and explore the prognosis of surgical excision treatment.

RESULTS

Among the new PLC cases between year 2002 and 2010, 1966 cases were male, whose average age of onset was 59.81; while 760 cases were female, whose average age of onset was 68.93. The crude incidence rate was 39.35/100 000 in male, which was higher than it in female, as 16.05/100 000. The difference showed statistical significance (U = 7.32, P < 0.01). The standardized incidence rates were 21.98/100 000 and 6.96/100 000 in male and female, respectively. The difference showed statistical significance (U = 221.76, P < 0.01). There were 2427 PLC death cases in total, including 1734 male death cases and 693 female death cases. The crude mortality rate was 34.71/100 000 in male and 14.64/100 000 in female, whose difference were statistically significant (U = 6.68, P < 0.01). The standardized mortality rate was 19.16/100 000 in male and 6.06/100 000 in female, whose difference were statistically significant (U = 207.18, P < 0.01). The incidence and mortality rates both increased apparently since males aging over 35 and females over 45. The 1 - 5 year survival rates of PLC patients were 33.95%, 23.11%, 17.04%, 14.42% and 12.29%, respectively. In the surgical excision treatment group (321 cases), the 1 - 5 year survival rates were separately 66.78%, 52.87%, 41.88%, 33.57% and 32.64%; while in the non-surgical treatment group (2405 cases), the 1 - 5 year survival rates were separately 29.04%, 18.58%, 13.30%, 11.16% and 9.01%. The differences in 1 - 5 year survival rates between surgical and non-surgical groups all showed statistical significance (U = 12.78, 10.52, 8.28, 5.56 and 5.12, respectively, P < 0.01).

CONCLUSION

The incidence of PLC was close to its mortality in Yangpu district of Shanghai. The male incidence and mortality rates were significantly higher than female corresponding rates. The surgical excision treatment could improve the prognosis of PLC.

摘要

目的

分析上海市杨浦区居民原发性肝癌（PLC）的发病率及生存率。

方法

2002年至2010年期间，本研究纳入上海市杨浦区9730736名常住人口（男性4996390名，女性4734346名）；其中确诊PLC病例2726例，死亡病例2427例。通过分析2002年至2010年期间新的PLC病例和死亡病例，计算PLC的发病率和死亡率。采用2000年第五次全国人口普查的人口构成对率进行标准化，以分析PLC患者的生存状况并探讨手术切除治疗的预后。

结果

在2002年至2010年期间的新PLC病例中，男性1966例，平均发病年龄为59.81岁；女性760例，平均发病年龄为68.93岁。男性粗发病率为39.35/10万，高于女性的16.05/10万。差异具有统计学意义（U = 7.32，P < 0.01）。男性和女性的标准化发病率分别为21.98/10万和6.96/10万。差异具有统计学意义（U = 221.76，P < 0.01）。共有2427例PLC死亡病例，其中男性死亡病例1734例，女性死亡病例693例。男性粗死亡率为34.71/10万，女性为14.64/10万，差异具有统计学意义（U = 6.68，P < 0.01）。男性标准化死亡率为19.16/10万，女性为6.06/10万，差异具有统计学意义（U = 207.18，P < 0.01）。35岁以上男性和45岁以上女性的发病率和死亡率均明显上升。PLC患者1至5年生存率分别为33.95%、23.11%、17.04%、14.42%和12.29%。手术切除治疗组（321例）1至5年生存率分别为66.78%、52.87%、41.88%、33.57%和32.64%；而非手术治疗组（2405例）1至5年生存率分别为29.04%、18.58%、13.30%、11.16%和9.01%。手术组和非手术组1至5年生存率的差异均具有统计学意义（U分别为12.78、10.52、8.28、5.56和5.12，P < 0.01）。