自发性丛集性头痛发作时局部一致性的改变：一项静息态功能磁共振成像研究。
Altered regional homogeneity in spontaneous cluster headache attacks: a resting-state functional magnetic resonance imaging study.
机构信息
Department of Neurology, Chinese People's Liberation Army General Hospital, Beijing, China.
出版信息
Chin Med J (Engl). 2012 Feb;125(4):705-9.
BACKGROUND
Functional neuroimaging study has opened an avenue for exploring the pathophysiology of cluster headache (CH). The aim of our study was to assess the changes in brain activity in CH patients by the regional homogeneity method using resting-state functional magnetic resonance imaging technique.
METHODS
The functional magnetic resonance imaging scans were obtained for 12 male CH patients with spontaneous right-sided headache attacks during "in attack" and "out of attack" periods and 12 age- and sex-matched normal controls. The data were analyzed to detect the altered brain activity by the regional homogeneity method using statistical parametric mapping software.
RESULTS
Altered regional homogeneity was detected in the anterior cingulate cortex, the posterior cingulate cortex, the prefrontal cortex, insular cortex, and other brain regions involved in pain processing and modulation among different groups.
CONCLUSION
It is referred that these brain regions with altered regional homogeneity might be related to the pain processing and modulation of CH.
背景
功能神经影像学研究为探索丛集性头痛（CH）的病理生理学开辟了一条途径。我们的研究目的是通过静息态功能磁共振成像技术，使用局部一致性方法评估 CH 患者大脑活动的变化。
方法
对 12 名男性 CH 患者在右侧自发性头痛发作期间的“发作期”和“发作间期”进行功能磁共振成像扫描，并与 12 名年龄和性别匹配的正常对照进行比较。使用统计参数映射软件，通过局部一致性方法分析数据，以检测不同组之间大脑活动的改变。
结果
在不同组之间，在前扣带回皮层、后扣带回皮层、前额叶皮层、岛叶皮层和其他参与疼痛处理和调节的脑区检测到局部一致性改变。
结论
这些局部一致性改变的脑区可能与 CH 的疼痛处理和调节有关。
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