Institute of Experimental Neurology, Department of Neuroradiology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.
Cephalalgia. 2010 Nov;30(11):1383-91. doi: 10.1177/0333102410365164. Epub 2010 Apr 7.
In this study, we investigated whether abnormalities of the brain resting-state networks (RSNs) occur in patients with episodic cluster headache (CH), outside the attacks of the disease.
RS fMRI scans were acquired from 13 CH patients and 15 healthy controls. RS fMRI data were analyzed using both independent component analysis (ICA) and a seed correlation analysis, starting from the hypothalamus and the thalamus.
The seed correlation analysis revealed increased functional connectivity within the networks identified starting from the hypothalami and thalami in CH patients versus controls. ICA analysis detected 11 RSNs with potential functional relevance. Among these networks, CH patients had decreased fluctuations within the sensorimotor and the primary visual network compared to controls (P-values 0.03-0.007). RSN abnormalities were significantly correlated with disease duration.
In CH patients a diffuse abnormality of brain functional connectivity is present, which extends beyond the antinoceptive system.
在这项研究中，我们研究了在发作性丛集性头痛（CH）患者的疾病发作之外，是否存在大脑静息状态网络（RSN）的异常。
从下丘脑和丘脑开始，我们对 13 名 CH 患者和 15 名健康对照者进行了 RS fMRI 扫描。使用独立成分分析（ICA）和种子相关分析对 RS fMRI 数据进行分析。
与对照组相比，种子相关分析显示 CH 患者的下丘脑和丘脑起始的网络内功能连接增加。ICA 分析检测到 11 个具有潜在功能相关性的 RSN。在这些网络中，与对照组相比，CH 患者的感觉运动和初级视觉网络内的波动降低（P 值为 0.03-0.007）。RSN 异常与疾病持续时间显著相关。
CH 患者存在弥散性脑功能连接异常，这种异常超出了抗伤害系统。
