Shu Yan, He Sen, Chen Xiao-ping, Lü Zheng-bing, Yang Rui, Liu Kai, Cui Kai-jun, Huang De-jia
Department of Cardiology, Sichuan University, Chengdu, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2012 Feb;40(2):125-30.
To explore the associations between fasting serum lipids and high-sensitivity C-reactive protein (hsCRP).
Serum triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and hsCRP were measured in residents of Chengdu, China. Subjects with potential factors which might influence lipids and hsCRP were excluded, 580 subjects [mean age (62.3 ± 6.6) years; male: 58.7%] were finally recruited by random sampling methods.
There was a weak positive relationship between TG and hsCRP (r = 0.108, P = 0.01) and a weak negative relationship between HDL-C and hsCRP (r = -0.197, P < 0.001), this was also true in the sub-group with BMI < 24 kg/m(2) (r = 0.236, -0.140 respectively, all P < 0.001). In subjects with BMI < 24 kg/m(2), the hsCRP concentration was significantly higher in subjects with higher TG or lower HDL-C (all P < 0.05). hsCRP increased in proportion with the degree of dyslipidemia. After adjusting for gender, age, TC, LDL-C, fasting blood glucose, systolic blood pressure, diastolic blood pressure, history of hypertension and diabetes, smoking and alcohol drinking, logistic regression analysis showed that the odds ratio for increased hsCRP was 1.970 in subjects with either increased TG or lower HDL-C (P = 0.105) and 9.098 in subjects with both higher TG or lower HDL-C levels (P = 0.031). However, the observed relationship between TG, HDL-C and hsCRP in subjects with BMI < 24 kg/m(2) could not be observed in subjects with subjects with BMI > 24 kg/m(2) despite significant more cardiovascular risk factors in these subjects.
A weak positive correlation between TG and hsCRP as well as a weak negative correlation between HDL-C and hsCRP was evidenced in the whole cohort suggesting dyslipidemia might be related to enhanced inflammatory status. However, this relationship is not observed in subjects with BMI > 24 kg/m(2) despite existence of more cardiovascular risk factors in these subjects.
探讨空腹血脂与高敏C反应蛋白（hsCRP）之间的关联。
对中国成都居民的血清甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和hsCRP进行检测。排除可能影响血脂和hsCRP的潜在因素，最终通过随机抽样方法招募了580名受试者[平均年龄（62.3±6.6）岁；男性：58.7%]。
TG与hsCRP之间存在弱正相关（r = 0.108，P = 0.01），HDL-C与hsCRP之间存在弱负相关（r = -0.197，P < 0.001），在体重指数（BMI）< 24 kg/m²的亚组中也是如此（分别为r = 0.236，-0.140，均P < 0.001）。在BMI < 24 kg/m²的受试者中，TG较高或HDL-C较低的受试者hsCRP浓度显著更高（均P < 0.05）。hsCRP随血脂异常程度成比例增加。在调整性别、年龄、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、空腹血糖、收缩压、舒张压、高血压和糖尿病病史、吸烟和饮酒等因素后，逻辑回归分析显示，TG升高或HDL-C降低的受试者hsCRP升高的优势比为1.970（P = 0.105），TG升高和HDL-C降低同时存在的受试者为9.098（P = 0.031）。然而，尽管BMI > 24 kg/m²的受试者心血管危险因素明显更多，但在这些受试者中未观察到BMI < 24 kg/m²受试者中TG、HDL-C与hsCRP之间的观察关系。
在整个队列中证实TG与hsCRP之间存在弱正相关以及HDL-C与hsCRP之间存在弱负相关，提示血脂异常可能与炎症状态增强有关。然而，尽管BMI > 24 kg/m²的受试者存在更多心血管危险因素，但在这些受试者中未观察到这种关系。
