Division of Endocrinology, Metabolism and Diabetes and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Biochimie. 2012 Oct;94(10):2097-103. doi: 10.1016/j.biochi.2012.03.019. Epub 2012 Apr 2.
It is well established that individuals with the metabolic syndrome have a significantly increased risk of cardiovascular disease and much effort has been expended to elicit the underlying mechanisms. Various studies have proposed that excessive or deficient physiological effects mediated by leptin make an important contribution, yet many paradoxical observations often preclude a clear definition of the role of leptin. This review article will briefly discuss principal and most recent evidence on direct and indirect regulation of the cardiovascular system by leptin, focusing on cardiac structural and functional as well as vascular effects.
众所周知，患有代谢综合征的个体患心血管疾病的风险显著增加，人们为此付出了大量努力来探究其潜在机制。各种研究表明，瘦素介导的生理作用过度或不足对其有重要贡献，但许多矛盾的观察结果往往使瘦素作用的明确定义变得困难。本文将简要讨论瘦素对心血管系统的直接和间接调节的主要和最新证据，重点关注心脏结构和功能以及血管效应。
