Kim H-S, Kang J-H, Jeung E-B, Yang M-P
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chunghuk National University, Cheongju, Chungbuk, Korea.
Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chunghuk National University, Cheongju, Chungbuk, Korea.
J Vet Intern Med. 2016 Sep;30(5):1589-1600. doi: 10.1111/jvim.14570. Epub 2016 Aug 30.
The concentrations of circulating adipokines in dogs with myxomatous mitral valve disease (MMVD) have not been investigated in detail.
To determine whether serum concentrations of adipokines differ between healthy dogs and dogs with MMVD and whether circulating concentrations depend on the severity of heart failure resulting from MMVD.
In the preliminary study, 30 healthy dogs and 17 client-owned dogs with MMVD, and in the subsequent study, 30 healthy dogs and 46 client-owned dogs with MMVD.
Prospective case-controlled observational study. In the preliminary study, serum concentrations of leptin, adiponectin, resistin, visfatin, interleukin (IL)-1β, IL-6, IL-10, IL-18, and tumor necrosis factor-α were measured. In the subsequent study, MMVD dogs were divided into three groups according to the International Small Animal Cardiac Health Council (ISACHC) classification, and serum concentrations of leptin and adiponectin were measured.
In the preliminary study, serum leptin and adiponectin concentrations differed significantly between dogs with MMVD and healthy dogs. Serum leptin (P = .0013) concentrations were significantly higher in dogs with MMVD than in healthy dogs, whereas adiponectin (P = .0009) concentrations were significantly lower in dogs with MMVD. However, we observed no significant differences in the other variables. In the subsequent study, dogs classified as ISACHC class 3 had higher serum concentrations of leptin (P = .0022) than healthy dogs but ISACHC class 1 or 2 dogs did not. Serum adiponectin concentrations were significantly lower in ISACHC class 1 (P < .0001) dogs than in healthy dogs, whereas adiponectin concentrations in ISACHC class 3 dogs were significantly higher than in ISACHC class 1 dogs (P = .0081).
Circulating concentrations of leptin and adiponectin might be altered in dogs with MMVD.
尚未对患有黏液瘤性二尖瓣疾病（MMVD）的犬循环脂肪因子浓度进行详细研究。
确定健康犬与患有MMVD的犬血清脂肪因子浓度是否存在差异，以及循环浓度是否取决于MMVD所致心力衰竭的严重程度。
在初步研究中，30只健康犬和17只患MMVD的客户拥有犬；在后续研究中，30只健康犬和46只患MMVD的客户拥有犬。
前瞻性病例对照观察研究。在初步研究中，测量血清瘦素、脂联素、抵抗素、内脂素、白细胞介素（IL）-1β、IL-6、IL-10、IL-18和肿瘤坏死因子-α的浓度。在后续研究中，根据国际小动物心脏健康委员会（ISACHC）分类将患MMVD的犬分为三组，并测量血清瘦素和脂联素的浓度。
在初步研究中，患MMVD的犬与健康犬的血清瘦素和脂联素浓度存在显著差异。患MMVD的犬血清瘦素浓度（P = 0.0013）显著高于健康犬，而患MMVD的犬脂联素浓度（P = 0.0009）显著低于健康犬。然而，我们在其他变量中未观察到显著差异。在后续研究中，ISACHC 3级犬的血清瘦素浓度（P = 0.0022）高于健康犬，但ISACHC 1级或2级犬则不然。ISACHC 1级犬的血清脂联素浓度（P < 0.0001）显著低于健康犬，而ISACHC 3级犬的脂联素浓度显著高于ISACHC 1级犬（P = 0.0081）。
患MMVD的犬循环中瘦素和脂联素浓度可能发生改变。
Zotero 插件
