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高踝臂指数与糖尿病微血管疾病的关联

[Association of a high ankle brachial index with microvascular diseases of diabetes].

作者信息

Li Xiang, Ren Hui, Wang Yu-zhen, Liu Yan-jun, Yang Xiao-ping, Liu Jian-qin, Xu Zhang-rong

机构信息

Department of Endocrinology, PLA Diabetes Center, PLA No. 306 Hospital, Beijing 100101, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2012 Jan 31;92(4):236-9.

Abstract

OBJECTIVE

To evaluate the association of a high ankle brachial index (ABI) with microvascular diseases of diabetes and to compare its strength with that of a low ABI.

METHODS

ABI was obtained in 3293 patients undergoing the screening of chronic complications at the Diabetic Center, No. 306 Hospital of PLA during the period of September 2003 to June 2010. The patient profiles and laboratory data were reviewed. The associations of ABI with microvascular diseases of diabetes were determined by univariate and stepwise Logistic regression analysis.

RESULTS

ABI was normal in 3060 patients. 44 had ABI measurements < 0.7, 139 had ABI measurements between 0.7 - 0.9, and 50 had ABI measurements > 1.3. Multivariate analysis indicated that the factors significantly associated with a high ABI were smoking (OR: 2.605; 95%CI: 1.458 - 4.656, P = 0.001) and systolic blood pressure (OR: 1.019; 95%CI: 1.005 - 1.033, P = 0.006). The conditions of nephropathy, neuropathy and retinopathy were not associated with a high ABI.

CONCLUSION

Diabetics with a high ABI carry not more adverse atherosclerotic risk factors and suffer no more severe microvascular diabetic complications than those with a normal ABI.

摘要

目的

评估高踝臂指数(ABI)与糖尿病微血管疾病的相关性,并将其与低ABI的相关性强度进行比较。

方法

2003年9月至2010年6月期间,在解放军第306医院糖尿病中心对3293例接受慢性并发症筛查的患者进行了ABI检测。回顾了患者的资料和实验室数据。通过单因素和逐步Logistic回归分析确定ABI与糖尿病微血管疾病的相关性。

结果

3060例患者ABI正常。44例患者ABI测量值<0.7,139例患者ABI测量值在0.7 - 0.9之间,50例患者ABI测量值>1.3。多因素分析表明,与高ABI显著相关的因素为吸烟(OR:2.605;95%CI:1.458 - 4.656,P = 0.001)和收缩压(OR:1.019;95%CI:1.005 - 1.033,P = 0.006)。肾病、神经病变和视网膜病变情况与高ABI无关。

结论

与ABI正常的糖尿病患者相比,高ABI的糖尿病患者不存在更多的不良动脉粥样硬化危险因素,也未患更严重的糖尿病微血管并发症。

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