Laboratory of Physiology, Institute of Biomedical Sciences, Federal University of Alfenas-MG, Brazil.
Neurosci Lett. 2012 May 10;516(1):114-8. doi: 10.1016/j.neulet.2012.03.070. Epub 2012 Apr 2.
Sickness behavior appears to be the expression of a central motivational state that reorganizes the organism's priorities to cope with infectious pathogens. To evaluate the effect of dipyrone in lipopolysaccharide (LPS)-induced sickness behavior, mice were subjected to the forced swim test (FST), tail suspension test (TST), dark-light box test, open field test, sucrose preference intake test and food intake test. LPS administration increased the immobility time in the TST, increased the time spent floating in the FST, and depressed locomotor activity in the open field test. Treatment with LPS decreased the total number of transitions made between the dark and light compartments of the apparatus and induced anhedonia and anorexia. Pre-treatment with dipyrone (10, 50, or 200 mg/kg) attenuated behavioral changes induced by LPS in the FST, TST, open field and light-dark box tests. In addition, dipyrone prevented anhedonia and anorexia in mice challenged with LPS. Considering that dipyrone attenuates LPS-induced behavioral changes, it is proposed that LPS-induced sickness behavior is dependent on the COX pathway.
患病行为似乎是一种中央动机状态的表达，它重新组织了生物体的优先级以应对感染病原体。为了评估双氯芬酸在脂多糖（LPS）诱导的患病行为中的作用，将小鼠进行强迫游泳试验（FST）、悬尾试验（TST）、明暗箱试验、旷场试验、蔗糖偏好摄入试验和食物摄入试验。LPS 给药增加了 TST 中的不动时间，增加了 FST 中的漂浮时间，并抑制了旷场试验中的运动活性。LPS 处理减少了装置的黑暗和明亮隔室之间的总转换次数，并引起快感缺失和厌食。双氯芬酸（10、50 或 200mg/kg）预处理减轻了 FST、TST、旷场和明暗箱试验中 LPS 诱导的行为改变。此外，双氯芬酸预防了 LPS 攻击小鼠的快感缺失和厌食。鉴于双氯芬酸减轻了 LPS 诱导的行为改变，因此提出 LPS 诱导的患病行为依赖于 COX 途径。
