Department of Psychiatry, The Saint Vincent Hospital, The College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea.
Neurosci Lett. 2012 May 10;516(1):124-9. doi: 10.1016/j.neulet.2012.03.072. Epub 2012 Apr 2.
Previous studies provided hippocampal shape analysis of Alzheimer's disease (AD) patients using automated segmentation techniques. However, the relationships between the hippocampal deformations and various cognitive impairments were not clear. The aim of this study was to investigate hippocampal shape changes and their relationship to cognitive impairments. Fifty-one drug-naïve patients with AD and 50 group-matched healthy control subjects underwent 3T MRI scanning, and the hippocampal volumes and deformations were compared between the groups. Additionally, we explored the correlation pattern between the hippocampal deformations and the cognitive dysfunctions in AD using the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K). AD subjects exhibited significant hippocampal deformations in the cornu ammnonis (CA1) and subiculum areas compared to those in healthy subjects (p<0.05, false discovery rate (FDR) corrected). Significant correlations were observed between hippocampal deformations in CA1 and subiculum areas and verbal immediate recall, verbal delayed recall, verbal recognition memory, and constructional recall scores (p<0.05, FDR corrected). This study was the first to explore the relationships between hippocampal deformations and various cognitive impairments of drug-naïve patients with AD. These structural changes in hippocampal CA1 and subiculum areas might be the core of the underlying neurobiological mechanisms of hippocampal dysfunction and their relevance to the various cognitive dysfunctions in AD.
先前的研究使用自动化分割技术对阿尔茨海默病（AD）患者的海马形状进行了分析。然而，海马变形与各种认知障碍之间的关系尚不清楚。本研究旨在探讨海马形状变化及其与认知障碍的关系。51 名未经药物治疗的 AD 患者和 50 名年龄匹配的健康对照组接受了 3T MRI 扫描，比较了两组之间的海马体积和变形。此外，我们使用韩国版 Consortium to Establish a Registry for Alzheimer's Disease（CERAD-K）探索了 AD 患者中海马变形与认知功能障碍之间的相关模式。与健康受试者相比，AD 受试者在角回（CA1）和下托区表现出明显的海马变形（p<0.05，经错误发现率（FDR）校正）。在 CA1 和下托区的海马变形与言语即时回忆、言语延迟回忆、言语识别记忆和结构回忆评分之间观察到显著相关性（p<0.05，经 FDR 校正）。本研究首次探讨了未经药物治疗的 AD 患者中海马变形与各种认知障碍之间的关系。海马 CA1 和下托区的这些结构变化可能是海马功能障碍的潜在神经生物学机制的核心，与 AD 中的各种认知功能障碍有关。
