Lim Hyun-Kook, Hong Seung Chul, Jung Won Sang, Ahn Kook Jin, Won Wang Youn, Hahn Changtae, Kim In Seong, Lee Chang Uk
Department of Psychiatry, The Saint Vincent Hospital, The College of Medicine, The Catholic University of Korea, Suwon, Korea.
Neuroreport. 2012 Apr 18;23(6):364-8. doi: 10.1097/WNR.0b013e328351ddc9.
Previous studies have carried out hippocampal shape analysis of amnestic mild cognitive impairment (aMCI) patients using automated segmentation techniques. However, the relationships between hippocampal deformations and various episodic memory impairments were not clear. The aim of this study was to investigate hippocampal shape changes and their relationships with various episodic memory impairments in aMCI. Hippocampal volumes and deformations were compared between the aMCI and the controls. In addition, we explored the correlation pattern between hippocampal deformations and cognitive dysfunctions in aMCI using a comprehensive neuropsychological battery. Patients with aMCI exhibited significant hippocampal deformations in the right cornu ammonis 1 (CA1) and subiculum areas compared with healthy individuals. Significant correlations were observed between constructional recall scores and the right CA1 and subiculum areas in aMCI. Verbal delayed recall scores were also significantly correlated with the left CA1 and subiculum areas in aMCI. This study was the first to explore the relationships between hippocampal deformations and various types of cognitive performances in aMCI. These structural changes in the hippocampal CA1 and subiculum areas might be at the core of underlying neurobiological mechanisms of hippocampal dysfunction and their relevance to verbal and visuospatial delayed recall in aMCI.
以往的研究使用自动分割技术对遗忘型轻度认知障碍（aMCI）患者进行了海马体形状分析。然而，海马体变形与各种情景记忆障碍之间的关系尚不清楚。本研究的目的是调查aMCI患者海马体形状的变化及其与各种情景记忆障碍的关系。比较了aMCI患者和对照组的海马体体积及变形情况。此外，我们使用一套全面的神经心理学测试，探究了aMCI患者海马体变形与认知功能障碍之间的相关模式。与健康个体相比，aMCI患者在右侧海马角1（CA1）和海马下托区域表现出明显的海马体变形。在aMCI患者中，构建回忆得分与右侧CA1和海马下托区域之间存在显著相关性。言语延迟回忆得分在aMCI患者中也与左侧CA1和海马下托区域显著相关。本研究首次探究了aMCI患者海马体变形与各种认知表现之间的关系。海马体CA1和海马下托区域的这些结构变化可能是海马体功能障碍潜在神经生物学机制的核心，以及它们与aMCI患者言语和视觉空间延迟回忆的相关性所在。
