Tokgöz S Alicura, Vuralkan E, Sonbay N D, Çalişkan M, Saka C, Beşalti Ö, Akin İ
First ENT Clinic, Ministry of Health Dişkapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
J Laryngol Otol. 2012 May;126(5):464-9. doi: 10.1017/S0022215112000382. Epub 2012 Apr 11.
This experimental study aimed to investigate the effects of vitamins E, B and C and L-carnitine in preventing cisplatin-induced ototoxicity.
Twenty-five adult, male, Wistar albino rats were randomly allocated to receive intraperitoneal cisplatin either alone or preceded by vitamins B, E or C or L-carnitine. Auditory brainstem response (i.e. hearing thresholds and wave I-IV intervals) and distortion product otoacoustic emissions (i.e. signal-to-noise ratios) were recorded before and 72 hours after cisplatin administration.
The following statistically significant differences were seen: control group pre- vs post-treatment wave I-IV interval values (p < 0.05); control vs vitamin E and B groups' I-IV interval values (p < 0.05); control vs other groups' hearing thresholds; vitamin E vs vitamin B and C and L-carnitine groups' hearing thresholds (p < 0.05); and vitamin B vs vitamin C and L-carnitine groups' hearing thresholds (p < 0.05). Statistically significant decreases were seen when comparing the initial and final signal-to-noise ratios in the control, vitamin B and L-carnitine groups (2000 and 3000 Hz; p < 0.01), and the initial and final signal-to-noise ratios in the control group (at 4000 Hz; p < 0.01).
Vitamins B, E and C and L-carnitine appear to reduce cisplatin-induced ototoxicity in rats. The use of such additional treatments to decrease cisplatin-induced ototoxicity in humans is still under discussion.
本实验研究旨在探讨维生素E、B、C以及左旋肉碱对预防顺铂所致耳毒性的作用。
将25只成年雄性Wistar白化大鼠随机分组，分别单独腹腔注射顺铂，或在注射顺铂前先给予维生素B、E、C或左旋肉碱。在注射顺铂前及注射后72小时记录听觉脑干反应（即听阈和波I-IV间期）以及畸变产物耳声发射（即信噪比）。
观察到以下具有统计学意义的数据差异：对照组治疗前后的波I-IV间期值（p < 0.05）；对照组与维生素E和B组的I-IV间期值（p < 0.05）；对照组与其他组的听阈；维生素E组与维生素B、C及左旋肉碱组的听阈（p < 0.05）；以及维生素B组与维生素C及左旋肉碱组的听阈（p < 0.05）。在比较对照组、维生素B组及左旋肉碱组初始和最终信噪比（2000和3000Hz；p < 0.01）以及对照组初始和最终信噪比（4000Hz；p < 0.01）时观察到具有统计学意义的降低。
维生素B、E、C以及左旋肉碱似乎可减轻顺铂对大鼠造成的耳毒性。关于在人类中使用此类附加治疗以降低顺铂所致耳毒性仍在讨论中。
