急性恒河猴巨细胞病毒（RhCMV）感染模式可预测长期 RhCMV 感染。
Patterns of acute rhesus cytomegalovirus (RhCMV) infection predict long-term RhCMV infection.
机构信息
Center for Comparative Medicine, University of California, Davis, Davis, California, USA.
出版信息
J Virol. 2012 Jun;86(11):6354-7. doi: 10.1128/JVI.00607-12. Epub 2012 Apr 4.
Abstract
We previously reported that long-term rhesus cytomegalovirus (RhCMV) excretion in infected macaques was related to UL/b' coding content. Acute biopsy specimens of the inoculation sites from the previous study have now been analyzed to determine whether there were acute phenotypic predictors of long-term RhCMV infection. Only in animals displaying acute endothelial tropism and neutrophilic inflammation was RhCMV excretion detected. The results imply that vaccinating against these early viral determinants would significantly impede long-term RhCMV infection.
摘要
我们之前报道过，受感染猕猴体内的长时恒河猴巨细胞病毒（RhCMV）排出与 UL/b' 编码含量有关。现在对之前研究中接种部位的急性活检标本进行了分析，以确定是否存在长期 RhCMV 感染的急性表型预测因子。只有在表现出急性血管内皮嗜性和嗜中性粒细胞炎症的动物中才检测到 RhCMV 排出。这些结果表明，针对这些早期病毒决定因素进行疫苗接种将显著阻碍长期 RhCMV 感染。
相似文献
1
Patterns of acute rhesus cytomegalovirus (RhCMV) infection predict long-term RhCMV infection.
J Virol. 2012 Jun;86(11):6354-7. doi: 10.1128/JVI.00607-12. Epub 2012 Apr 4.
2
Limited dissemination and shedding of the UL128 complex-intact, UL/b'-defective rhesus cytomegalovirus strain 180.92.
J Virol. 2014 Aug;88(16):9310-20. doi: 10.1128/JVI.00162-14. Epub 2014 Jun 4.
3
Open reading frames carried on UL/b' are implicated in shedding and horizontal transmission of rhesus cytomegalovirus in rhesus monkeys.
J Virol. 2011 May;85(10):5105-14. doi: 10.1128/JVI.02631-10. Epub 2011 Mar 9.
4
Immunohistochemical studies of productive rhesus cytomegalovirus infection in rhesus monkeys (Macaca mulatta) infected with simian immunodeficiency virus.
Vet Pathol. 1999 Jan;36(1):51-6. doi: 10.1354/vp.36-1-51.
5
Pathogenesis of Wild-Type-Like Rhesus Cytomegalovirus Strains following Oral Exposure of Immune-Competent Rhesus Macaques.
J Virol. 2022 Feb 9;96(3):e0165321. doi: 10.1128/JVI.01653-21. Epub 2021 Nov 17.
6
Rhesus and human cytomegalovirus glycoprotein L are required for infection and cell-to-cell spread of virus but cannot complement each other.
J Virol. 2011 Mar;85(5):2089-99. doi: 10.1128/JVI.01970-10. Epub 2010 Dec 29.
7
Rhesus cytomegalovirus encodes seventeen microRNAs that are differentially expressed in vitro and in vivo.
Virology. 2012 Apr 10;425(2):133-42. doi: 10.1016/j.virol.2012.01.009. Epub 2012 Feb 2.
8
Reevaluation of the coding potential and proteomic analysis of the BAC-derived rhesus cytomegalovirus strain 68-1.
J Virol. 2012 Sep;86(17):8959-73. doi: 10.1128/JVI.01132-12. Epub 2012 Jun 20.
9
Experimental coinfection of rhesus macaques with rhesus cytomegalovirus and simian immunodeficiency virus: pathogenesis.
J Virol. 2002 Aug;76(15):7661-71. doi: 10.1128/jvi.76.15.7661-7671.2002.
10
rhesus cytomegalovirus (macacine herpesvirus 3)-associated facial neuritis in simian immunodeficiency virus-infected rhesus macaques (Macaca mulatta).
Vet Pathol. 2015 Jan;52(1):217-23. doi: 10.1177/0300985814529313. Epub 2014 Mar 31.
引用本文的文献
1
Myeloid cell tropism enables MHC-E-restricted CD8 T cell priming and vaccine efficacy by the RhCMV/SIV vaccine.
Sci Immunol. 2022 Jun 24;7(72):eabn9301. doi: 10.1126/sciimmunol.abn9301. Epub 2022 Jun 17.
2
Pathogenesis of Wild-Type-Like Rhesus Cytomegalovirus Strains following Oral Exposure of Immune-Competent Rhesus Macaques.
J Virol. 2022 Feb 9;96(3):e0165321. doi: 10.1128/JVI.01653-21. Epub 2021 Nov 17.
3
Recent Approaches and Strategies in the Generation of Anti-human Cytomegalovirus Vaccines.
Methods Mol Biol. 2021;2244:403-463. doi: 10.1007/978-1-0716-1111-1_19.
4
In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome.
PLoS Pathog. 2020 Nov 24;16(11):e1008666. doi: 10.1371/journal.ppat.1008666. eCollection 2020 Nov.
5
Human cytomegalovirus-vectored vaccines against HIV.
Curr Opin HIV AIDS. 2019 Mar;14(2):137-142. doi: 10.1097/COH.0000000000000524.
6
Natural history of postnatal rhesus cytomegalovirus shedding by dams and acquisition by infant rhesus monkeys.
PLoS One. 2018 Oct 24;13(10):e0206330. doi: 10.1371/journal.pone.0206330. eCollection 2018.
7
Cytomegaloviral hypophysitis in a simian immunodeficiency virus-infected rhesus macaque (Macacca mulatta).
J Med Primatol. 2017 Dec;46(6):364-367. doi: 10.1111/jmp.12289. Epub 2017 Jul 3.
8
Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques.
PLoS Pathog. 2016 Nov 9;12(11):e1006014. doi: 10.1371/journal.ppat.1006014. eCollection 2016 Nov.
9
Examining the species-specificity of rhesus macaque cytomegalovirus (RhCMV) in cynomolgus macaques.
PLoS One. 2015 Mar 30;10(3):e0121339. doi: 10.1371/journal.pone.0121339. eCollection 2015.
10
Limited dissemination and shedding of the UL128 complex-intact, UL/b'-defective rhesus cytomegalovirus strain 180.92.
J Virol. 2014 Aug;88(16):9310-20. doi: 10.1128/JVI.00162-14. Epub 2014 Jun 4.
本文引用的文献
1
Open reading frames carried on UL/b' are implicated in shedding and horizontal transmission of rhesus cytomegalovirus in rhesus monkeys.
J Virol. 2011 May;85(10):5105-14. doi: 10.1128/JVI.02631-10. Epub 2011 Mar 9.
2
Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection.
Rev Med Virol. 2010 Jul;20(4):202-13. doi: 10.1002/rmv.655.
3
Efficient replication of rhesus cytomegalovirus variants in multiple rhesus and human cell types.
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19950-5. doi: 10.1073/pnas.0811063106. Epub 2008 Dec 8.
4
A heterologous DNA prime/protein boost immunization strategy for rhesus cytomegalovirus.
Vaccine. 2008 Nov 5;26(47):6013-25. doi: 10.1016/j.vaccine.2008.07.103. Epub 2008 Aug 27.
5
Cytomegalovirus cell tropism.
Curr Top Microbiol Immunol. 2008;325:63-83. doi: 10.1007/978-3-540-77349-8_4.
6
Protein coding content of the UL)b' region of wild-type rhesus cytomegalovirus.
Virology. 2008 Mar 30;373(1):181-8. doi: 10.1016/j.virol.2007.10.040. Epub 2008 Feb 20.
7
Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection.
Rev Med Virol. 2007 Jul-Aug;17(4):253-76. doi: 10.1002/rmv.535.
8
Genomic sequence of rhesus cytomegalovirus 180.92: insights into the coding potential of rhesus cytomegalovirus.
J Virol. 2006 Apr;80(8):4179-82. doi: 10.1128/JVI.80.8.4179-4182.2006.
9
Human cytomegalovirus UL131-128 genes are indispensable for virus growth in endothelial cells and virus transfer to leukocytes.
J Virol. 2004 Sep;78(18):10023-33. doi: 10.1128/JVI.78.18.10023-10033.2004.
10
Rescue of human cytomegalovirus strain AD169 tropism for both leukocytes and human endothelial cells.
J Gen Virol. 2003 Jun;84(Pt 6):1431-1436. doi: 10.1099/vir.0.19055-0.
Zotero 插件