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急性恒河猴巨细胞病毒（RhCMV）感染模式可预测长期 RhCMV 感染。

Patterns of acute rhesus cytomegalovirus (RhCMV) infection predict long-term RhCMV infection.

机构信息

Center for Comparative Medicine, University of California, Davis, Davis, California, USA.

出版信息

J Virol. 2012 Jun;86(11):6354-7. doi: 10.1128/JVI.00607-12. Epub 2012 Apr 4.

DOI:10.1128/JVI.00607-12
PMID:22491451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3372188/
Abstract

We previously reported that long-term rhesus cytomegalovirus (RhCMV) excretion in infected macaques was related to UL/b' coding content. Acute biopsy specimens of the inoculation sites from the previous study have now been analyzed to determine whether there were acute phenotypic predictors of long-term RhCMV infection. Only in animals displaying acute endothelial tropism and neutrophilic inflammation was RhCMV excretion detected. The results imply that vaccinating against these early viral determinants would significantly impede long-term RhCMV infection.

摘要

我们之前报道过，受感染猕猴体内的长时恒河猴巨细胞病毒（RhCMV）排出与 UL/b' 编码含量有关。现在对之前研究中接种部位的急性活检标本进行了分析，以确定是否存在长期 RhCMV 感染的急性表型预测因子。只有在表现出急性血管内皮嗜性和嗜中性粒细胞炎症的动物中才检测到 RhCMV 排出。这些结果表明，针对这些早期病毒决定因素进行疫苗接种将显著阻碍长期 RhCMV 感染。

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