Institute of Molecular and Cell Biology, 61 Biopolis Dr., Singapore 138673.
Cell Res. 2012 Aug;22(8):1218-20. doi: 10.1038/cr.2012.59. Epub 2012 Apr 10.
Aging is a key risk factor in neurodegenerative disease; however, little is known about cellular pathways that mediate age-associated degeneration of the brain. The Bonini lab has identified a conserved microRNA, miR-34, that plays a neuroprotective role in the aging Drosophila brain and suggests that it functions in temporal control of gene expression.
衰老是神经退行性疾病的一个关键风险因素;然而,人们对介导与年龄相关的大脑退化的细胞途径知之甚少。Bonini 实验室已经鉴定出一种保守的 microRNA,miR-34,它在衰老的果蝇大脑中发挥神经保护作用,并表明它在时间控制基因表达中起作用。