时间至关重要：microRNAs 与年龄相关的神经退行性变。
Time is of the essence: microRNAs and age-associated neurodegeneration.
机构信息
Institute of Molecular and Cell Biology, 61 Biopolis Dr., Singapore 138673.
出版信息
Cell Res. 2012 Aug;22(8):1218-20. doi: 10.1038/cr.2012.59. Epub 2012 Apr 10.
Abstract
Aging is a key risk factor in neurodegenerative disease; however, little is known about cellular pathways that mediate age-associated degeneration of the brain. The Bonini lab has identified a conserved microRNA, miR-34, that plays a neuroprotective role in the aging Drosophila brain and suggests that it functions in temporal control of gene expression.
摘要
衰老是神经退行性疾病的一个关键风险因素；然而，人们对介导与年龄相关的大脑退化的细胞途径知之甚少。Bonini 实验室已经鉴定出一种保守的 microRNA，miR-34，它在衰老的果蝇大脑中发挥神经保护作用，并表明它在时间控制基因表达中起作用。
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