Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Antimicrob Agents Chemother. 2012 Jun;56(6):3406-8. doi: 10.1128/AAC.00582-12. Epub 2012 Apr 9.
The in vitro activity of ceftaroline, a recently introduced parenteral cephalosporin, was assessed versus 1,750 isolates of Streptococcus pneumoniae recovered from patients with a variety of pneumococcal infections in 43 U.S. medical centers during 2010-2011. Using a breakpoint of ≤ 0.5 μg/ml for susceptibility, all of the isolates were found to be susceptible to ceftaroline. Ceftaroline MICs were consistently 16-fold lower than ceftriaxone MICs. Among the isolates characterized in this investigation, 38.9% were found to be nonsusceptible to penicillin (oral penicillin breakpoints) and 9.1% were nonsusceptible to ceftriaxone (nonmeningitis breakpoints).
2010 年至 2011 年期间，在美国 43 个医疗中心，研究人员评估了新引入的注射用头孢菌素头孢洛林对从患有各种肺炎球菌感染的患者中分离出的 1750 株肺炎链球菌的体外活性。结果显示，所有分离株对头孢洛林的敏感性检测折点为≤0.5μg/ml，均符合敏感性标准。头孢洛林 MIC 值始终比头孢曲松 MIC 值低 16 倍。在本研究中，38.9%的分离株对青霉素（口服青霉素折点）不敏感，9.1%的分离株对头孢曲松（非脑膜炎折点）不敏感。
