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头孢噻肟、头孢曲松、头孢他啶、头孢匹罗和青霉素对肺炎链球菌分离株的体外活性。

In vitro activities of cefotaxime, ceftriaxone, ceftazidime, cefpirome, and penicillin against Streptococcus pneumoniae isolates.

作者信息

Barry A L, Brown S D, Novick W J

机构信息

Clinical Microbiology Institute, Tualatin, Oregon 97062, USA.

出版信息

Antimicrob Agents Chemother. 1995 Oct;39(10):2193-6. doi: 10.1128/AAC.39.10.2193.

DOI:10.1128/AAC.39.10.2193
PMID:8619565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162912/
Abstract

The in vitro activities of four extended-spectrum cephalosporins and benzyl penicillin were evaluated against 698 clinical isolates of Streptococcus pneumoniae, including 130 (19%) penicillin-intermediate and 84 (12%) penicillin-resistant strains. Cefotaxime and ceftriaxone were essentially identical in their antipneumococcal activities: both were active against penicillin-susceptible strains and most penicillin-intermediate strains. Cefpirome was twice as potent as cefotaxime and ceftriaxone against penicillin-resistant strains. Ceftazidime was 8- to 16-fold less active than cefotaxime and ceftriaxone against S. pneumoniae in vitro, and thus, its spectrum included only penicillin-susceptible strains.

摘要

评估了四种广谱头孢菌素和苄青霉素对698株肺炎链球菌临床分离株的体外活性，其中包括130株（19%）青霉素中介株和84株（12%）耐青霉素株。头孢噻肟和头孢曲松的抗肺炎球菌活性基本相同：两者对青霉素敏感株和大多数青霉素中介株均有活性。头孢匹罗对耐青霉素株的活性是头孢噻肟和头孢曲松的两倍。在体外，头孢他啶对肺炎链球菌的活性比头孢噻肟和头孢曲松低8至16倍，因此，其抗菌谱仅包括青霉素敏感株。

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Antimicrobial resistance of Streptococcus pneumoniae in the United States, 1979-1987. The Pneumococcal Surveillance Working Group.1979 - 1987年美国肺炎链球菌的抗菌药物耐药性。肺炎球菌监测工作组。
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