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利用魁北克长白猪中连锁标记基因座（Phi、Po2、Pgd）预测氟烷（Hal）基因型。

Prediction of the halothane (Hal) genotypes by means of linked marker loci (Phi, Po2, Pgd) in Quebec Landrace pigs.

作者信息

Doizé F, Roux I, Martineau-Doizé B, DeRoth L

机构信息

Laboratoire de Biomédecine Comparée, Faculté de Médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec.

出版信息

Can J Vet Res. 1990 Oct;54(4):397-9.

PMID:2249173
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1255682/
Abstract

Quebec Landrace pigs (n = 896) were halothane tested and blood samples were taken for the determination of Phi, Po2 and Pgd phenotypes. The incidence of the halothane positive pigs was 5.3%. The frequencies of the favorable alleles PhiA, Po2S and PdgA were respectively 29.2%, 39.6% and 64.4%. The highest linkage disequilibrium was found between Hal-Phi (0.0606) followed by Hal-Pgd (0.0428) and Hal-Po2 (-0.0308). Alleles PhiB, PgdB and Po2F were associated respectively with 97%, 81% and 74% of Haln haplotypes. It was concluded that a selection in order to increase the favorable marker loci PhiA and PgdA would reduce the Haln frequency in Quebec Landrace pigs.

摘要

对896头魁北克长白猪进行了氟烷检测，并采集血样以测定Phi、Po2和Pgd表型。氟烷阳性猪的发生率为5.3%。有利等位基因PhiA、Po2S和PdgA的频率分别为29.2%、39.6%和64.4%。发现Hal-Phi之间的连锁不平衡最高（0.0606），其次是Hal-Pgd（0.0428）和Hal-Po2（-0.0308）。等位基因PhiB、PgdB和Po2F分别与97%、81%和74%的Haln单倍型相关。得出的结论是，为增加有利标记位点PhiA和PgdA而进行的选择将降低魁北克长白猪中Haln的频率。

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Prediction of the halothane (Hal) genotypes by means of linked marker loci (Phi, Po2, Pgd) in Quebec Landrace pigs.利用魁北克长白猪中连锁标记基因座（Phi、Po2、Pgd）预测氟烷（Hal）基因型。
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本文引用的文献

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Incidence of porcine stress syndrome susceptibility at the st. Cyrille record of performance station in Québec.魁北克圣西里尔性能记录站猪应激综合征易感性的发生率。
Can Vet J. 1982 May;23(5):168.
2
Genetic variation at a pig serum protein locus, Po-2 and its assignment to the Phi, Hal, S, H, Pgd linkage group.猪血清蛋白基因座Po - 2的遗传变异及其在Phi、Hal、S、H、Pgd连锁群中的定位。
Anim Blood Groups Biochem Genet. 1983;14(1):27-36. doi: 10.1111/j.1365-2052.1983.tb01057.x.
3
Estimation of linkage disequilibrium in randomly mating populations.随机交配群体中连锁不平衡的估计。
Heredity (Edinb). 1974 Oct;33(2):229-39. doi: 10.1038/hdy.1974.89.
4
Trends in economic traits, halothane sensitivity, blood group and enzyme systems of Swiss Landrace and Large White pigs.瑞士长白猪和大白猪经济性状、氟烷敏感性、血型及酶系统的变化趋势
Anim Blood Groups Biochem Genet. 1985;16(4):285-96. doi: 10.1111/j.1365-2052.1985.tb01480.x.
5
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Anim Blood Groups Biochem Genet. 1985;16(4):265-83. doi: 10.1111/j.1365-2052.1985.tb01479.x.
6
Simultaneous phenotyping of pig plasma alpha-protease inhibitors (PI1, PO1A, PO1B, PI2) and four other proteins (PO2, TF, CP, HPX) by a simple method of 2D horizontal electrophoresis.通过二维水平电泳的简单方法对猪血浆α-蛋白酶抑制剂（PI1、PO1A、PO1B、PI2）和其他四种蛋白质（PO2、TF、CP、HPX）进行同步表型分析。
Anim Genet. 1987;18(3):197-211. doi: 10.1111/j.1365-2052.1987.tb00760.x.
7
Porcine malignant hyperthermia: false negatives in the halothane test.
Am J Vet Res. 1987 Mar;48(3):488-91.
8
Extensive genetic polymorphism of four plasma alpha-protease inhibitors in pigs and evidence for tight linkage between the structural loci of these inhibitors.猪体内四种血浆α-蛋白酶抑制剂的广泛遗传多态性以及这些抑制剂结构基因座之间紧密连锁的证据。
Anim Genet. 1986;17(2):135-57. doi: 10.1111/j.1365-2052.1986.tb00733.x.
9
Associations between marker genotypes, halothane reaction, creatine kinase activity and meat quality characters in a sample of German Landrace pigs.德国长白猪样本中标记基因型、氟烷反应、肌酸激酶活性与肉质性状之间的关联
Anim Blood Groups Biochem Genet. 1985;16(4):319-27. doi: 10.1111/j.1365-2052.1985.tb01483.x.
10
The effect of a selected locus on linked neutral loci.一个选定基因座对连锁中性基因座的影响。
Genetics. 1977 Apr;85(4):753-88. doi: 10.1093/genetics/85.4.753.

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