非裔美国人的遗传学、动脉僵硬和血压综述。
A review of genetics, arterial stiffness, and blood pressure in African Americans.
机构信息
Division of Cardiology, Department of Medicine, Lillehei Heart Institute, University of Minnesota, 4-106 NHH, 312 Church Street, Minneapolis, MN 55455, USA.
出版信息
J Cardiovasc Transl Res. 2012 Jun;5(3):302-8. doi: 10.1007/s12265-012-9362-y. Epub 2012 Apr 11.
Abstract
The prevalence of hypertension in African Americans in the USA is among the highest in the world and increasing. The identification of genes and pathways regulating blood pressure in African Americans has been challenging. An early predictor of hypertension is arterial stiffness. The prevalence of arterial stiffness is significantly higher in African Americans compared to Caucasians. Approximately 20 % of the variance in arterial stiffness is estimated to be heritable. Identifying genes and biological pathways regulating arterial stiffness may provide insight into the genetics underlying the increased risk of hypertension in African Americans. This paper reviews the genetic findings to date in the area of arterial stiffness and blood pressure in African Americans with an emphasis on the current limitations and new efforts to move the field forward.
摘要
美国非裔美国人的高血压患病率位居世界前列，且呈上升趋势。确定调节非裔美国人血压的基因和途径一直具有挑战性。动脉僵硬度是高血压的早期预测指标。与白种人相比，非裔美国人的动脉僵硬度明显更高。据估计，动脉僵硬度的大约 20%可遗传。确定调节动脉僵硬度的基因和生物学途径可能有助于深入了解非裔美国人高血压风险增加的遗传基础。本文回顾了迄今为止在非裔美国人动脉僵硬度和血压领域的遗传发现，重点讨论了当前的局限性和推动该领域发展的新努力。
相似文献
1
A review of genetics, arterial stiffness, and blood pressure in African Americans.
J Cardiovasc Transl Res. 2012 Jun;5(3):302-8. doi: 10.1007/s12265-012-9362-y. Epub 2012 Apr 11.
2
A whole genome scan for pulse pressure/stroke volume ratio in African Americans: the HyperGEN study.
Am J Hypertens. 2007 Apr;20(4):398-402. doi: 10.1016/j.amjhyper.2006.10.001.
3
The effects of genes implicated in cardiovascular disease on blood pressure response to treatment among treatment-naive hypertensive African Americans in the GenHAT study.
J Hum Hypertens. 2016 Sep;30(9):549-54. doi: 10.1038/jhh.2015.121. Epub 2016 Jan 21.
4
Assessment of the interaction of heritability of volume load and left ventricular mass: the HyperGEN offspring study.
J Hypertens. 2007 Jul;25(7):1397-402. doi: 10.1097/HJH.0b013e328126851e.
5
Blood pressure variation in blacks: genetic factors.
Semin Nephrol. 1996 Mar;16(2):83-93.
6
Arterial stiffness is greater in African Americans than in whites: evidence from the Forsyth County, North Carolina, ARIC cohort.
Am J Hypertens. 2004 Apr;17(4):304-13. doi: 10.1016/j.amjhyper.2003.12.004.
7
Effect of acute aerobic exercise and histamine receptor blockade on arterial stiffness in African Americans and Caucasians.
J Appl Physiol (1985). 2017 Feb 1;122(2):386-395. doi: 10.1152/japplphysiol.01115.2015. Epub 2016 Dec 15.
8
Heritability of arterial stiffness in black and white American youth and young adults.
Am J Hypertens. 2007 Oct;20(10):1065-72. doi: 10.1016/j.amjhyper.2007.05.013.
9
A genome-wide association study of hypertension and blood pressure in African Americans.
PLoS Genet. 2009 Jul;5(7):e1000564. doi: 10.1371/journal.pgen.1000564. Epub 2009 Jul 17.
10
The nature and nurture of blood pressure in African Americans.
Ethn Dis. 2003 Spring;13(2):297-8.
引用本文的文献
1
Fully automatic carotid arterial stiffness assessment from ultrasound videos based on machine learning.
Phys Eng Sci Med. 2023 Mar;46(1):151-164. doi: 10.1007/s13246-022-01206-3. Epub 2023 Feb 14.
2
Living Arrangement: a Contributor to Vascular Disease in Asymptomatic African American Women.
J Ga Public Health Assoc. 2019 Fall;7(2):139-148. doi: 10.20429/jgpha.2019.070220.
3
New Markers of Carotid Thickening in Hypertension.
Arq Bras Cardiol. 2021 Jan;116(1):66-67. doi: 10.36660/abc.20201335.
4
Racial disparities in cardiovascular disease risk: mechanisms of vascular dysfunction.
Am J Physiol Heart Circ Physiol. 2019 Oct 1;317(4):H777-H789. doi: 10.1152/ajpheart.00126.2019. Epub 2019 Aug 9.
5
Genetics of Hypertension in African Americans and Others of African Descent.
Int J Mol Sci. 2019 Mar 2;20(5):1081. doi: 10.3390/ijms20051081.
6
Diastolic wall strain is associated with incident heart failure in African Americans: Insights from the atherosclerosis risk in communities study.
J Cardiol. 2018 May;71(5):477-483. doi: 10.1016/j.jjcc.2017.11.004. Epub 2017 Dec 6.
7
Hypertension in African Americans.
Curr Cardiol Rep. 2017 Oct 28;19(12):129. doi: 10.1007/s11886-017-0933-z.
8
Increased Proximal Aortic Diameter is Associated With Risk of Cardiovascular Events and All-Cause Mortality in Blacks The Jackson Heart Study.
J Am Heart Assoc. 2017 Jun 21;6(6):e005005. doi: 10.1161/JAHA.116.005005.
9
Recent advances in understanding hypertension development in sub-Saharan Africa.
J Hum Hypertens. 2017 Aug;31(8):491-500. doi: 10.1038/jhh.2017.18. Epub 2017 Mar 23.
10
Perceived Control Predicts Pulse Pressure in African American Men: The Baltimore Study of Black Aging.
Ethn Dis. 2015 Aug 7;25(3):263-70. doi: 10.18865/ed.25.3.263.
本文引用的文献
1
Disruption of Na+,HCO₃⁻ cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca²⁺ sensitivity, and hypertension development in mice.
Circulation. 2011 Oct 25;124(17):1819-29. doi: 10.1161/CIRCULATIONAHA.110.015974. Epub 2011 Sep 26.
2
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
Nature. 2011 Sep 11;478(7367):103-9. doi: 10.1038/nature10405.
3
Association of self-reported race/ethnicity and genetic ancestry with arterial elasticity: the Multi-Ethnic Study of Atherosclerosis (MESA).
J Am Soc Hypertens. 2011 Nov-Dec;5(6):463-72. doi: 10.1016/j.jash.2011.07.005. Epub 2011 Sep 3.
4
Racial differences in arterial stiffness among adolescents and young adults with type 2 diabetes.
Pediatr Diabetes. 2012 Mar;13(2):170-5. doi: 10.1111/j.1399-5448.2011.00798.x. Epub 2011 Jul 25.
5
Ethnic differences in arterial wave reflections and normative equations for augmentation index.
Hypertension. 2011 Jun;57(6):1108-16. doi: 10.1161/HYPERTENSIONAHA.110.166348. Epub 2011 May 2.
6
Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium.
Hum Mol Genet. 2011 Jun 1;20(11):2285-95. doi: 10.1093/hmg/ddr113. Epub 2011 Mar 21.
7
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.
Hum Mol Genet. 2011 Jun 1;20(11):2273-84. doi: 10.1093/hmg/ddr092. Epub 2011 Mar 4.
8
Health behaviors and racial disparity in blood pressure control in the national health and nutrition examination survey.
Hypertension. 2011 Mar;57(3):383-9. doi: 10.1161/HYPERTENSIONAHA.110.161950. Epub 2011 Feb 7.
9
Five blood pressure loci identified by an updated genome-wide linkage scan: meta-analysis of the Family Blood Pressure Program.
Am J Hypertens. 2011 Mar;24(3):347-54. doi: 10.1038/ajh.2010.238. Epub 2010 Dec 9.
10
Gender and ethnic differences in arterial compliance in patients with intermittent claudication.
J Vasc Surg. 2010 Mar;51(3):610-5. doi: 10.1016/j.jvs.2009.09.059.
Zotero 插件