Wassel Christina L, Jacobs David R, Duprez Daniel A, Bluemke David A, Sibley Christopher T, Criqui Michael H, Peralta Carmen A
University of California-San Diego, La Jolla, CA, USA.
J Am Soc Hypertens. 2011 Nov-Dec;5(6):463-72. doi: 10.1016/j.jash.2011.07.005. Epub 2011 Sep 3.
African Americans have a disproportionate burden of hypertension compared with white, whereas data on Hispanics is less well-defined. Mechanisms underlying these differences are unclear, but could be in part because of ancestral background and vascular function. We studied 660 African Americans and 635 Hispanics from the Multi-Ethnic Study of Atherosclerosis (MESA) with complete data on genetic ancestry, pulse pressure (PP), and large and small arterial elasticity (LAE, SAE). LAE and SAE were obtained using the HDI PulseWave CR-2000 Research CardioVascular Profiling Instrument. Among African Americans, higher European ancestry was marginally associated with higher LAE (P = .05) and lower PP (P = .05); results for LAE were attenuated after adjustment for potential mediators (P = .30). Among Hispanics, higher Native American ancestry was associated with higher SAE (P = .0006); higher African ancestry was marginally associated with lower SAE (P = .07). Ancestry was not significantly associated with LAE or PP in Hispanics. Among African Americans, higher European ancestry may be associated with less large artery damage, as measured by LAE and PP, although these associations warrant further study. Among Hispanics, ancestry is strongly associated with SAE. Future studies should consider genetic ancestry when studying hypertension in race/ethnic minorities, particularly among Hispanics.
与白人相比，非裔美国人患高血压的负担过重，而关于西班牙裔的数据则不太明确。这些差异背后的机制尚不清楚，但可能部分归因于祖先背景和血管功能。我们对来自动脉粥样硬化多民族研究（MESA）的660名非裔美国人和635名西班牙裔进行了研究，他们有关于遗传血统、脉压（PP）以及大动脉和小动脉弹性（LAE、SAE）的完整数据。LAE和SAE使用HDI PulseWave CR - 2000研究用心血管分析仪器获得。在非裔美国人中，较高的欧洲血统与较高的LAE（P = 0.05）和较低的PP（P = 0.05）存在微弱关联；在对潜在中介因素进行调整后，LAE的结果减弱（P = 0.30）。在西班牙裔中，较高的美洲原住民血统与较高的SAE相关（P = 0.0006）；较高的非洲血统与较低的SAE存在微弱关联（P = 0.07）。在西班牙裔中，血统与LAE或PP无显著关联。在非裔美国人中，较高的欧洲血统可能与通过LAE和PP衡量的较少的大动脉损伤有关，尽管这些关联值得进一步研究。在西班牙裔中，血统与SAE密切相关。未来在研究种族/族裔少数群体（尤其是西班牙裔）的高血压时应考虑遗传血统。
