Crews J C, Denson D D
Department of Anesthesia, University of Cincinnati College of Medicine, Ohio.
Cancer. 1990 Dec 15;66(12):2642-4. doi: 10.1002/1097-0142(19901215)66:12<2642::aid-cncr2820661229>3.0.co;2-b.
MS-Contin (Purdue-Fredrick, Norwalk, CT) is a controlled-release preparation of morphine sulfate that has demonstrated efficacy in the management of chronic cancer pain problems. It has recently come to the attention of the authors that MS-Contin represents a potential source of opioid abuse through the extraction and intravenous injection of the morphine from this preparation. The authors describe a simple aqueous extraction method that was used to quantitatively determine the extent to which morphine could be obtained from MS-Contin tablets.
美施康定（普渡-弗雷德里克公司，诺沃克，康涅狄格州）是硫酸吗啡控释制剂，已证明对慢性癌痛问题的管理有效。作者最近注意到，美施康定可能通过从该制剂中提取和静脉注射吗啡而成为阿片类药物滥用的一个潜在源头。作者描述了一种简单的水提取方法，该方法用于定量测定从美施康定片剂中获取吗啡的程度。
