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糖尿病患者的脑血管病诊断与管理。

The diagnosis and management of cerebrovascular disease in diabetes.

机构信息

VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06519, USA.

出版信息

Curr Diab Rep. 2012 Jun;12(3):314-23. doi: 10.1007/s11892-012-0271-x.

DOI:10.1007/s11892-012-0271-x
PMID:22492061
Abstract

Cerebrovascular disease is a leading cause of morbidity and mortality in diabetes. Compared with nondiabetic patients, diabetic patients have at least twice the risk for stroke, earlier onset of symptoms, and worse functional outcomes. Approximately 20 % of diabetic patients will die from stroke, making it one of the leading causes of death in this population. Effective strategies for primary and secondary prevention of stroke have been developed in research cohorts that included both diabetic and nondiabetic patients. Nevertheless, prevention in diabetes has some specific considerations. In this paper, we summarize evidence to guide the diagnosis and management of stroke in diabetic patients. We propose that diabetic stroke patients should have a robust risk assessment to target interventions, like other patients with cerebrovascular disease, but with special attention to glycemic control and lifestyle modification.

摘要

脑血管疾病是糖尿病患者发病率和死亡率的主要原因之一。与非糖尿病患者相比,糖尿病患者发生中风的风险至少增加一倍,症状出现更早,功能预后更差。大约 20%的糖尿病患者会死于中风,使其成为该人群的主要死亡原因之一。在包括糖尿病和非糖尿病患者在内的研究队列中,已经制定了用于中风一级和二级预防的有效策略。然而,糖尿病的预防需要一些特殊的考虑。在本文中,我们总结了指导糖尿病患者中风诊断和管理的证据。我们建议,糖尿病中风患者应进行全面的风险评估,以确定干预目标,就像其他脑血管疾病患者一样,但要特别注意血糖控制和生活方式的改变。

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本文引用的文献

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Duration of diabetes and risk of ischemic stroke: the Northern Manhattan Study.糖尿病病程与缺血性脑卒中风险:北方曼哈顿研究。
Stroke. 2012 May;43(5):1212-7. doi: 10.1161/STROKEAHA.111.641381. Epub 2012 Mar 1.
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Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus.
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Diabetic aggravation of stroke and animal models.糖尿病对中风的加重作用及动物模型
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9
Diabetes-mediated middle cerebral artery remodeling is restored by linagliptin: Interaction with the vascular smooth muscle cell endothelin system.利格列汀可恢复糖尿病介导的大脑中动脉重塑:与血管平滑肌细胞内皮素系统的相互作用。
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Hyperglycemia / hypoglycemia-induced mitochondrial dysfunction and cerebral ischemic damage in diabetics.糖尿病患者中高血糖/低血糖诱导的线粒体功能障碍及脑缺血损伤
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