Vondrová H, Bartos V, Saudek F, Vanĕk I
Katedra neurologie, Institutu pro dalsí vzdĕláváni lékarů a farmaceutů, Praha.
Cas Lek Cesk. 1990 Nov 9;129(45):1416-20.
Sixteen type I diabetics were followed up from the neurological aspect and by electromyography for 6 to 42 months following successful combined transplantation of the pancreas and kidney. Before transplantation all patients suffered from medium severe to severe peripheral polyneuropathy, grade 3-5 according to the commonly used quantitative classification. All patients reported after transplantation subjective improvement, e.g. of the muscular strength or steadiness of gait. In six patients the clinical and in eight patients the electromyographic finding improved by one grade, in four patients at least the conductivity in the nerves of the upper extremities improved. In four patients the neurological and electromyographic finding did not change; none of the patients after successful transplantation deteriorated. The authors discuss the favourable effect not only of elimination of the uraemic syndrome, but also the effect of the improved carbohydrate metabolism on regenerating processes in the peripheral nervous system.
对16例I型糖尿病患者在成功进行胰腺和肾脏联合移植后进行了6至42个月的神经学随访及肌电图检查。移植前，所有患者均患有中度至重度外周多神经病，根据常用的定量分类为3 - 5级。所有患者在移植后均报告有主观改善，如肌肉力量或步态稳定性的改善。6例患者的临床症状改善1级，8例患者的肌电图检查结果改善1级，4例患者至少上肢神经传导改善。4例患者的神经学和肌电图检查结果未改变；成功移植后无患者病情恶化。作者讨论了不仅尿毒症综合征消除的有利影响，还讨论了改善的碳水化合物代谢对外周神经系统再生过程的影响。
