Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038, USA.
Chem Asian J. 2012 Jun;7(7):1502-14. doi: 10.1002/asia.201200035. Epub 2012 Apr 11.
The transformation of C-H bonds into other chemical bonds is of great significance in synthetic chemistry. C-H bond-activation processes provide a straightforward and atom-economic strategy for the construction of complex structures; as such, they have attracted widespread interest over the past decade. As a prevalent directing group in the field of C-H activation, the amide group not only offers excellent regiodirecting ability, but is also a potential C-N bond precursor. As a consequence, a variety of nitrogen-containing heterocycles have been obtained by using these reactions. This Focus Review addresses the recent research into the amide-directed tandem C-C/C-N bond-formation process through C-H activation. The large body of research in this field over the past three years has established it as one of the most-important topics in organic chemistry.
C-H 键转化为其他化学键在合成化学中具有重要意义。C-H 键活化过程为构建复杂结构提供了一种直接的、原子经济性的策略；因此，在过去十年中引起了广泛的关注。酰胺基作为 C-H 活化领域中一种常见的导向基团，不仅提供了优异的区域导向能力，而且还是潜在的 C-N 键前体。因此，通过这些反应可以得到各种含氮杂环。本综述重点介绍了酰胺导向的通过 C-H 活化的串联 C-C/C-N 键形成过程的最新研究进展。该领域在过去三年中的大量研究使其成为有机化学中最重要的课题之一。
