Department of Public Health, Academic Medical Center, Amsterdam, The Netherlands.
Pediatr Blood Cancer. 2012 Aug;59(2):211-5. doi: 10.1002/pbc.24163. Epub 2012 Apr 10.
Patients with Sickle cell disease (SCD) exhibit signs of poor growth, increased susceptibility to infection and recurrent episodes of painful vaso-occlusive crises. Micronutrient deficiencies may increase susceptibility to these outcomes. We conducted a systematic review to assess the strength of evidence for improved outcomes related to micronutrient interventions. Six randomized-controlled trials of moderate quality met the inclusion criteria. Zinc supplementation was associated with improved growth and decreased incidence of infection and is a promising intervention in the management of SCD patients. Omega-3 fatty acid supplementation was associated with limited reduction in vaso occlusive crises. This review identifies key knowledge gaps, which are important research priorities for nutritional interventions.
镰状细胞病（SCD）患者表现出生长不良、易感染和反复发作的血管阻塞性危象的迹象。微量营养素缺乏可能会增加这些后果的易感性。我们进行了一项系统评价，以评估与微量营养素干预相关的改善结果的证据强度。符合纳入标准的有 6 项中等质量的随机对照试验。锌补充剂与改善生长和减少感染发生率有关，是 SCD 患者管理中很有前途的干预措施。ω-3 脂肪酸补充剂与血管阻塞性危象的有限减少有关。本综述确定了关键的知识空白，这些空白是营养干预的重要研究重点。
