Anwar Muhammad Zohaib, Sehar Anoosha, Rehman Inayat-Ur, Khalid Mohammad Hassan
Bioinformation. 2012;8(5):243-5. doi: 10.6026/97320630008243. Epub 2012 Mar 17.
Locating genes on a chromosome is important for understanding the gene function and its linkage and recombination. Knowledge of gene positions on chromosomes is necessary for annotation. The study is essential for disease genetics and genomics, among other aspects. Currently available software's for calculating recombination frequency is mostly limited to the range and flexibility of this type of analysis. GENE LOCATER is a fully customizable program for calculating recombination frequency, written in JAVA. Through an easy-to-use interface, GENE LOCATOR allows users a high degree of flexibility in calculating genetic linkage and displaying linkage group. Among other features, this software enables user to identify linkage groups with output visualized graphically. The program calculates interference and coefficient of coincidence with elevated accuracy in sample datasets.
The database is available for free at http://www.moperandib.com.
在染色体上定位基因对于理解基因功能及其连锁和重组很重要。了解基因在染色体上的位置对于注释是必要的。这项研究对于疾病遗传学和基因组学等方面至关重要。目前可用的计算重组频率的软件大多局限于这类分析的范围和灵活性。GENE LOCATER是一个用JAVA编写的用于计算重组频率的完全可定制程序。通过易于使用的界面，GENE LOCATER允许用户在计算遗传连锁和显示连锁群方面具有高度的灵活性。该软件的其他功能包括，能够通过图形可视化输出帮助用户识别连锁群。该程序在样本数据集中以更高的精度计算干涉和并发系数。
