Bhargava Nidhi, Erill Ivan
Department of Biological Sciences, University of Maryland Baltimore County,1000 Hilltop Circle,Baltimore,MD 21250,USA.
Bioinformation. 2010 Jul 6;5(2):49-51. doi: 10.6026/97320630005049.
Locating transcription factor binding sites in genomic sequences is a key step in deciphering transcription networks. Currently available software for site search is mostly server-based, limiting the range and flexibility of this type of analysis. xFITOM is a fully customizable program for locating binding sites in genomic sequences written in C++. Through an easy-to-use interface, xFITOM that allows users an unprecedented degree of flexibility in site search. Among other features,it enables users to define motifs by mixing real sites and IUPAC consensus sequences,to search the annotated sequences of unfinished genomes and to choose among 11 different search algorithms.
XFITOM IS AVAILABLE FOR DOWNLOAD AT: http://research.umbc.edu/˜erill.
在基因组序列中定位转录因子结合位点是解读转录网络的关键步骤。目前可用的用于位点搜索的软件大多基于服务器，限制了这类分析的范围和灵活性。xFITOM是一个用C++编写的用于在基因组序列中定位结合位点的完全可定制程序。通过一个易于使用的界面，xFITOM在位点搜索方面为用户提供了前所未有的灵活性。除其他功能外，它还允许用户通过混合真实位点和国际纯粹与应用化学联合会（IUPAC）一致序列来定义基序，搜索未完成基因组的注释序列，并在11种不同的搜索算法中进行选择。
可在以下网址下载xFITOM：http://research.umbc.edu/˜erill 。
